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Fertility Nutrition Fertility Therapies

How Ubiquinol Can Improve Your Chances of Conception

Dalene Barton - Certified Herbalist, Birth Doula
August 2, 2021
Reviewed by Christine Traxler, MD

Are you among the thousands of people told you have poor egg or poor sperm health? Perhaps you are over the age of 35 and trying to conceive. If this is you, you just came across crucial information that may greatly increase your chances of healthy conception and a healthy baby.

The most biologically-active form of coenzyme Q10, known as Ubiquinol, has been shown through several studies to improve both egg and sperm health, while playing a key role in protecting DNA at a cellular level.

CoQ10 is considered by many to be the miracle nutrient because almost every living cell relies on it for energy production. An important fact that you may not know is that the body requires certain levels of CoQ10 to function properly. If these blood levels drop, the body becomes more susceptible to disease and premature aging. This is why CoQ10 is so vital to the health of both the male and female reproductive system- most importantly egg and sperm health. But to truly understand why CoQ10 is so important to health, you must first learn what it is and why its most biologically active form, Ubiquinol, is a key player in improving egg and sperm health.

What is CoQ10 & How Does it Work?

CoQ10 is a powerful antioxidant that is produced naturally by the body, but it is also available as a nutritional supplement. It is present in the membrane of almost every cell in the body and is required for mitochondrial ATP synthesis, which is responsible for creating cellular energy.

There are two forms of CoQ10, ubiquinone and Ubiquinol. CoQ10 starts off as ubiquinone and then is converted within the cell to the more powerful Ubiquinol. Ubiquinol is considered one of the most powerful antioxidants.

CoQ10 is a considered a “vitamin-like” nutrient because it is synthesized in the membrane of human cells, but it is also obtained in small amounts through dietary intake. It is most abundantly found in organ meats, but can also be found in dark leafy green vegetables like spinach, kale and broccoli, nuts, seafood, and meat, though the amounts of leafy greens a person would need to consume to obtain therapeutic amounts of CoQ10 would be high. That is why nutritional supplementation of CoQ10 and/or Ubiquinol is suggested. Most all CoQ10 supplements available are in the form of ubiquinone. Ubiquinol is different in that it is the most biologically active form of coenzyme Q10 and does not need to be converted by the body. Ubiquinol is eight times more potent than ubiquinone.

Studies have shown that the presence of the most biologically active form of coenzyme Q10 Ubiquinol in the cell membrane may help reduce cell and DNA damage caused by free radicals, which has been shown to reduce blood pressure and improve egg health, sperm health and, in turn, embryo quality.

Free radicals are unstable molecules that can damage cell structures. In normal everyday life free radicals are produced from the activity in our bodies (for example, free radicals are made during ATP synthesis for energy production) but chemicals in our surrounding environment can also create free radicals. It is said that each cell in our body is attacked about 10,000 times a day by free radicals, accelerating the aging process.

As we age, the ability of the body to produce and metabolize ubiquinone to Ubiquinol declines. In turn so do energy levels and cellular health. This may be due to increased metabolic demand as the body ages, poor nutritional intake, gene mutation, and oxidative stress. Some reports have stated that this decline becomes most apparent around the age of 40, but may begin as early as 20 years of age. So, what can be done now to increase levels of CoQ10? Supplement with Ubiquinol.

Why Ubiquinol is Superior to CoQ10 Alone

Remember how I mentioned that most all CoQ10 supplements are made of the inactive form known as ubiquinone? Well, by supplementing with the most biologically active form of coenzyme Q10 (Ubiquinol), you are able to bypasses the body having to use energy to convert the ubiquinone to Ubiquinol. Ubiquinol provides a strong first-stage antioxidant effect against cellular oxidative damage.

Ubiquinol needs to be replenished regularly to maintain cellular health and proper function of the entire body. Ubiquinol is readily and easily absorbed in the intestinal tract, making it more “bioavailable” than ubiquinone. Studies have shown that Ubiquinol is eight times more potent than ubiquinone.

For people under the age of 30, the body may be able to easily convert CoQ10 supplements from ubiquinone to Ubiquinol. But for those who are older, suffering from chronic disease or exposed to excessive oxidative stress, Ubiquinol may be a superior choice of supplementation because it can readily replenish Ubiquinol stores.

Ubiquinol to Improve Reproductive Health and Boost Fertility

Several diseases associated with infertility and reproductive dysfunction are linked to oxidative stress including endometriosis, unexplained infertility, PCOS, POF, menstrual cycle irregularities, preterm labor, recurrent miscarriage, egg health, sperm health, and motility. Several studies show that antioxidant supplementation can reduce oxidative stress, which positively affects the outcome of each of these issues.

Click here to shop for Fertilica™ Ubiquinol

Start With Egg and Sperm Health!

In order to have a healthy pregnancy and baby, both the ova and sperm must be healthy! The cells of a developing embryo just after conception cannot divide properly if either ova or sperm health is poor, resulting in miscarriage. If the ova and sperm are very poor in health, conception may not be able to occur, even through IVF.

Researchers think that CoQ10 supplementation may help cells function more normally and divide more normally by restoring normal energy to the mitochondria in each cell. This is very important when considering conception and how the first stages of life are dependent on proper cell division.

Ova (Egg) Health
For women over the age of 35, ovum (egg) health begins to dramatically decline. Once a woman is over 40 years old, ovum health continues to decline and at a quickening pace. Each ovum is but a single cell, the health of each ovum matters greatly. Within each ovum is the blueprint of a future child; DNA is the genetic code inherent to the healthy life of a human being yet to be. Ubiquinol has been shown to inhibit DNA oxidation (damage from free radicals), thus protecting the genetic code.

A study published in Fertility and Sterility showed that supplementation of 600 mg of CoQ10 daily by older women improved both egg quality and fertilization rates. Other studies published in Fertility and Sterility also showed the same improvements in the ova of older mice.

A preliminary study of mice by Dr. Robert Casper and colleagues at Samuel Lunenfeld Research Institute, showed that CoQ10 supplementation on mid-aged female mice resulted in more pregnancies and more babies per litter. “They found that when CoQ10 was given to 52-week-old mice – about mid-age for a mouse – their eggs appeared to rejuvenate. There were significantly more egg follicles in the old mice treated with the CoQ10…”

Sperm Count & Health
Just as each ovum contains DNA, so does each sperm, the other vital half to the creation of a child. CoQ10 deficiency may lead to not only damaged DNA within the sperm, but low levels affect the ability of sperm to swim, known as motility. Ubiquinol supplementation has a twofold support system for sperm health, one it is protective and second it supports motility by increasing cellular energy.

CoQ10 is found in the highest concentrations inside the mitochondria of all cells. For sperm, this is located in the midsection, the area where energy production occurs that powers the tail whip. The higher the blood levels of CoQ10, the greater the sperm’s ability to be strong swimmers. A study in 2009 showed that low levels of CoQ10 in the seminal fluid impacts sperm motility, but supplementation with CoQ10 greatly improved and restored sperm motility in men with very low levels of sperm motility.

One study showed that healthy sperm, with normal morphology (shape), incubated with 50 mg of CoQ10 had a significant increase in sperm motility. That same study also showed that 17 patients with low fertilization rates who supplemented with 60 mg of CoQ10 daily for 103 days had a significant improvement in fertilization rates.

Defective sperm function in infertile men has been shown to be directly associated with increased free radical stress. This is where Ubiquinol supplementation may greatly help to protect sperm health, as well as the health of all the cells that make up the reproductive organs, and the entire body.

Note from Kimberly Langdon M.D., OB/GYN:

While mice studies are not always indicative of human response, CoQ10 as an antioxidant alone would be protective of eggs in general as described in the 2018 study out if China in the journal Reproductive Biology and Endocrinology below.

“CoQ10 pretreatment resulted in significantly lower gonadotrophin requirements and higher peak E2 levels. Women in CoQ10 group had increased number of retrieved oocytes (4, IQR 2–5), higher fertilization rate (67.49%) and more high-quality embryos (1, IQR 0–2); p < 0.05. Significantly less women treated with CoQ10 had cancelled embryo transfer because of poor embryo development than controls (8.33% vs. 22.89%, p = 0.04) and more women from treatment group had available cryopreserved embryos (18.42% vs. 4.3%, p = 0.012). The clinical pregnancy and live birth rates per embryo transfer and per one complete stimulation cycle tended to be higher in CoQ10 group but did not achieve statistical significance.”

In addition Langdon shares, “Since fertilization depends on good eggs being retrieved, by default one would argue that the eggs were better in the treated group compared to placebo because more were fertilized and produced better embryos. Furthermore, more cyropreserved embryos are dependent on good eggs.”

I spite of inconclusive studies with human or animal subjects, Ubiquinol is a safe supplement with so many proven benefits as an anti-oxidant that when faced with egg health or advanced maternal age, supplementing is worth considering. In any case, all people should be on it for all of its benefits to other body systems including the heart, etc.

Supplementing with Ubiquinol

Ubiquinol is easily altered by both light and air. Once it is exposed to light and air, it converts back to the oxidized form of CoQ10, ubiquinone. Because of this, development of a bulk Ubiquinol supplement for consumers proved to be difficult. Today, through advanced technology, scientists have developed a process that has perfected stabilization of Ubiquinol, keeping intact its active electron-rich benefits through a specialized softgel that protects it from oxidation.

The general suggested daily dose of Ubiquinol for the average person is 100 mg per day. For those who are older or suspect decreased levels of CoQ10 due to health issues, supplementation may be started at 200-300 mg per day for two weeks. After two weeks, blood plasma levels plateau and dosage may be lowered to 100 mg per day, as maintenance.

Click here to shop for Fertilica™ Ubiquinol

The Importance of Diet
Supplementation of Ubiquinol alone cannot serve its purpose if healthy diet and lifestyle are not in place. The role of diet in cellular health and fertility is truly the foundation for proper reproductive function. We find that without eating a whole food Fertility Diet, Ubiquinol cannot be as effective. Learn all about the Fertility Diet here…

Supplementing with Other Antioxidants
For those who want to improve reproductive function, learning how supplementing with “sister” (other types) antioxidants is also important. Ubiquinol is not the only antioxidant that is important to fertility, so are Lipoic acid, vitamin E, vitamin C, and Glutathione. Antioxidants rely on one another to revive each other, so each one can continue on protecting cellular health and function. While Ubiquinol is considered the most powerful of all antioxidants, these other antioxidants play their own important key role in proper function of the body, including egg and sperm health. Learn more about each of these important antioxidants here…

Reduce Exposure to Free Radicals
The human body is bombarded by free radicals daily. Not only can Ubiquinol, antioxidants and diet help improve cellular health and energy, but so can reducing exposure to free radicals. Avoid car exhaust, chemical pollution, smoking, alcohol, excessive exercise, and hydrogenated oils.

References

  • Barry, Dr. Robert, The Power of Ubiquinol. Health Point Press, 2010.
  • Sinatra, Stephen T., M.D.F.A.C.C. The Coenzyme Q10 Phenomenon. McGraw Hill, 1998.
  • Gleicher, N., Weghofer, A., & Barad, D. H. (2011). Defining ovarian reserve to better understand ovarian aging. Reproductive Biology and Endocrinology, 9(1), 23. doi:10.1186/1477-7827-9-23 Retrieved from: https://rbej.biomedcentral.com/track/pdf/10.1186/1477-7827-9-23?site=rbej.biomedcentral.com
  • Balercia, G., Mancini, A., Paggi, F., Tiano, L., Pontecorvi, A., Boscaro, M., . . . Littarru, G. P. (2009). Coenzyme Q10 and male infertility. Journal of Endocrinological Investigation, 32(7), 626-632. doi:10.1007/bf03346521 Retrieved from: https://link.springer.com/article/10.1007/BF03346521
  • Ben-Meir, A., Chong, J., Borrego-Alvarez, A., Moley, K., Jurisicova, A., & Casper, R. (2011). CoQ10 treatment can improve fertility and oocyte quality in old mice. Fertility and Sterility, 96(3). doi:10.1016/j.fertnstert.2011.07.415 Retrieved from: https://www.fertstert.org/article/S0015-0282(11)01512-3/fulltext
  • Xu, Y., Nisenblat, V., Lu, C., Li, R., Qiao, J., Zhen, X., & Wang, S. (2018). Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled trial. Reproductive biology and endocrinology : RB&E, 16(1), 29. doi:10.1186/s12958-018-0343-0. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870379/
  • Burstein, E., Perumalsamy, A., Bentov, Y., Esfandiari, N., Jurisicova, A., & Casper, R. (2009). Co-enzyme Q10 supplementation improves ovarian response and mitochondrial function in aged mice. Fertility and Sterility, 92(3). doi:10.1016/j.fertnstert.2009.07.121 Retrieved from: https://www.fertstert.org/article/S0015-0282(09)01557-X/fulltext
  • Langdon-Cull, K. (June 12, 2019). Personal Communication.
  • Rodriguez, H., C.H., C.M.T. (n.d.). Antioxidants and Fertility. Retrieved from: http://natural-fertility-info.com/antioxidants-and-fertility.html

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About the Author

Dalene Barton - Certified Herbalist, Birth Doula

Practicing natural health and herbalism for over 18 years, Dalene received her training and herbal certification under the guidance of Lynn Albers at Yarmony Mt. Herbal College in Colorado in 2000. She went on to become a Certified Birth Doula at Birthingway College of Midwifery in Portland, Oregon in 2007. As a Birth Doula, Dalene has helped to bring many new lives in to this world. Dalene has written 280+ fertility articles and with her vast array of herbal and holistic healing knowledge has helped 1000's of women on their journey to Motherhood.

5 Steps To Improve Your Fertility Naturally

  • Learn the 5 different areas to focus on for optimal fertility health
  • Learn how to support hormonal health with herbs and essential oils
  • Tips on transitioning to a whole food fertility diet.
  • Self-care therapies to support your reproductive health

@NaturalFertilityInfo

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☕Reproductive Support Tea contains herbs that support, tone, and nourish the female reproductive system while supporting hormone balance.

It’s a soothing and effective fertility tea that provides just the right mixture of beneficial fertility herbs designed to help:

1️⃣ Nourish the uterus*

2️⃣ Support fallopian tube health.*

3️⃣ Help maintain normal ovarian function.*

4️⃣ Encourage normal uterine health.*

5️⃣ Support hormonal balance.

Type ‘TEA’ in the comments below if you would like 10% off your first order or Reproductive Support Tea and I will DM you a discount link. 👇👇

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👇3 Ways To Naturally Support Ovulation 👇

Lack of ovulation is one of the most common causes of infertility.

BUT you can help support your body to regularly ovulate again when hormonal health is found.

Here are some steps you can take to support yourself….

1️⃣ Eat healthy fats like avocado, chia, flax, nuts & seeds

2️⃣ Eat an abundance of whole foods 🥦🍉🥗🍇

3️⃣ Increase circulation to the reproductive system through exercise, Self Fertility Massage and castor oil packs.

👇 To learn more on how to support your fertility naturally, type STEPS in the comments below to join my free mini-course - 5 Steps To Improve Your Fertility Naturally, where I go into detail on each of the steps you can take to support your fertility cycle. 👇

#ovulation #periodhealth #naturalfertility #fertilitytips #fertilitydiet

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🌱 Ashwagandha is one of my favorite herbs for stress support while trying to conceive. 

It is easy to use and the calming effects can be felt pretty quickly after starting the herb. 

➡️ The hormonal support results take a bit longer, as with any hormone supportive herb, but is wonderful for both women and men who are experiencing high stress and hormone imbalances. 

Type ASH in the comments below and I will share which Ashwagandha I recommend and how to use it for fertility support. 👇👇

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Q: I have a 24 day cycle. What is this saying about my fertility?

A: Swipe left for our answer...

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⭐ 3 Benefits of Vitex for Fertility…

1️⃣ Regulates hormones: Vitex, also known as chasteberry, is known to regulate the production of hormones such as luteinizing hormone and prolactin, which can help to balance out estrogen and progesterone levels, promoting fertility.

2️⃣ Improves ovulation: Vitex can help to regulate the menstrual cycle and improve ovulation in women with irregular cycles or polycystic ovary syndrome (PCOS).

3️⃣ Decreases symptoms of PMS: Vitex can also help to reduce the severity of symptoms associated with premenstrual syndrome (PMS), such as cramps, breast tenderness, and mood swings, which can improve overall health and well-being.

Want to know which Vitex I recommend and how to use it? Type VITEX in the comments below 👇

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🌱 Red raspberry leaf has been used by midwives for fertility for generations. Some of the most well known benefits of raspberry leaf for reproductive support include… 

1️⃣ Regulating menstrual cycles: Red raspberry leaf is believed to help balance hormones and regulate menstrual cycles, making it easier for women to conceive.

2️⃣ Strengthening the uterus: Red raspberry leaf is rich in vitamins and minerals, including iron and vitamin C, which are believed to help strengthen the uterus and prepare it for pregnancy.

3️⃣ Improving egg quality: Some studies suggest that red raspberry leaf may improve egg quality and increase the chances of conception.

4️⃣ Reducing morning sickness: Red raspberry leaf is also believed to help reduce the symptoms of morning sickness, which can be especially beneficial for women who are trying to conceive.

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🧪 Xenohormones are chemicals that mimic the effects of hormones in the body. 

They can disrupt the endocrine system, which controls the production, transport, and function of hormones. 🚫

This can lead to a variety of health problems, including fertility issues. 

Examples of xenohormones include certain pesticides, plastics, and phthalates. 🕯️

Exposure to these chemicals can affect the production of hormones such as estrogen and testosterone, which play key roles in fertility. 

Xenohormones can also affect ovulation and implantation of a fertilized egg, leading to infertility. 

It would be best to avoid these chemicals as much as possible. 

👇👇To  learn more about which chemicals to avoid and which products are most important to replace type in ‘TOXIC’ in the comments below to get my guide to Creating a Healthy Home for Fertility Pregnancy & Family 👇👇

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Jan 28

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5 Steps you can take to help support your fertility naturally…. 👇

1️⃣ Cleanse and prepare the body for conception

2️⃣ Nourish the body with fertility supportive foods

3️⃣ Protect and remove any substances that are causing harm

4️⃣ Learn how to fertility chart and read your monthly cycle

5️⃣ Add lifestyle habits that help to support fertility health

🌼 To learn more on how to support your fertility naturally, type STEPS in the comments below to join my free mini-course - 5 Steps To Improve Your Fertility Naturally, where I go into detail on each of the 5 steps. 👇

#naturalfertility #fertilitytips #gettingpregnant #hormonehealth #hormonalhealth

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The body is always giving us feedback to what is happening inside. How regularly you go to the bathroom shares a lot about your digestive health.... as does a bloated belly or gas. Your period or monthly cycle can share a lot about your hormonal state. Your skin can share how your liver is doing. And so on. What have you learned from listening to your body?

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🕯️Chemicals in candles, such as paraffin and phthalates, can release volatile organic compounds (VOCs) when burned. 

Some research suggests that certain VOCs, such as phthalates, may disrupt hormone balance by mimicking estrogen and other hormones in the body. 🚫

It’s always a good idea to choose candles made from natural materials, such as beeswax or soy wax, which produce fewer VOCs. 🐝

naturalfertilityinfo

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Jan 27

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5 Steps you can take to help support your fertility naturally…. 👇

1️⃣ Cleanse and prepare the body for conception

2️⃣ Nourish the body with fertility supportive foods

3️⃣ Protect and remove any substances that are causing harm

4️⃣ Learn how to fertility chart and read your monthly cycle

5️⃣ Add lifestyle habits that help to support fertility health

🌼 To learn more on how to support your fertility naturally, type STEPS in the comments below to join my free mini-course - 5 Steps To Improve Your Fertility Naturally, where I go into detail on each of the 5 steps. 👇

#naturalfertility #fertilitytips #gettingpregnant #hormonehealth #hormonalhealth

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Preparing for pregnancy is one of the best steps you can take for a healthy pregnancy and child. Here are some steps to help you get started…. 👇

1️⃣ Eat a diet high in fiber. More fruits and veggies

Fiber helps the body to get rid of excess hormones and fruits and veggies are packed with fiber. They also are very hydrating and have lots of nutrients. All are useful for someone with heavy cycles. 

2️⃣ Learn about your fertility cycle through tracking and charting

Fertility charting will help you to understand your current hormonal state, when or if you are ovulating and other information about your cycle that will help to bring clarity to your fertility path. 

3️⃣ Fertility Cleanse 1-2x per year

The first phase of the Fertility Cleanse is a great way to help support the liver in it’s natural ability to get rid of excess hormones. The second phase focuses on the uterus and helping the uterus to cleanse and increase circulation.

👇 To learn more about the Fertility Cleansing type CLEANSE in the comments below and I will send you my Guide To Fertility Cleansing. 👇 

#hormonehealth #hormonalhealth #periodhealth #naturalfertility #fertilitytips #fertilitydiet

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Jan 26

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💡It can be completely normal for your menstrual cycle to vary in length slightly from month to month! 

Ovulation may come a day before or a day later even in normal some cycles. 

We actually expect to see natural variations between menstrual cycles. 

Early ovulation can be concerning, however, when/if it consistently happens. 

➡️ If you would like to learn what you can do to help balance a short follicular phase type EARLY in the comments below and I will send you a link to my guide….👇👇

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Jan 26

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Are you experiencing fibroids? 👇 Type FIBROID in the comments below and I will send you a link to my natural guide. 🌱

#fibroid #fibroids #naturalfertility #fibroidfertility #fibroiddiet

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Intimacy may not be something at the top of your mind with everything else you are doing to TTC. But connection with your partner and you feeling.... good is important. Here are some natural ways to support libido if the stress of baby making has made things tense in the bedroom.

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Jan 25

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When in doubt get it checked out. 

One of the most common reasons I suggest women to see their doctors is when they are experiencing  a heavy period that doesn’t stop after 5-7 days and has heavy flow. 

There are many different reasons this could be happening, but we first want to make sure it isn’t something that requires medical assistance before going on to healthy lifestyle support.

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Jan 25

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Ovarian cysts are more common than you think, and there are ways you can support your body naturally. Type CYSTS in the comments below and I will send you the natural steps you can take to support your self.

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Jan 24

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🌱 One of my favorite ways to support fertility and hormone health is through herbs. 

Over the past 20+ years that I have been an herbalist I have seen what herbs can do to help turn someone’s health around. 

When it comes to fertility there are a lot of different herbs that you can use. But they all have different actions. There is no one herb that fits all for fertility. 

That is one of the reasons I make herbal blends & formulas. 

Three of my favorite herbs are vitex, maca and shatavari, but they each have different effects on the body. 

So the key to success with fertility herbs is to first figure out what is going on in your body and then you can pick the right herbal formula for you. 

You can do this by charting your fertility (I have a lot of posts about fertility charting on my feed as well as my website) and also paying attention to your period. 🩸

To learn more about my herbal formulas for fertility support type HERBS in the comments below and I’ll share a link to my formulas 👇👇

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Jan 24

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👇READ THIS if you have a regular period but still haven’t gotten pregnant…. 

The answer is YES. The menstruation phase of a monthly fertility cycle is only one stage of the cycle. 

There are many other times of the month that are even more important like: 

🌸 Follicular phase: When the lining is growing and follicles are maturing

🌸 Ovulation: When the egg is released

🌸 Implantation: When the fertilized egg implants

🌸 Luteal phase: The time period between ovulation and the next cycle needs to be long enough for implantation to occur. 

Wondering how to start supporting your fertility naturally? 

👇 To learn more on how to support your fertility naturally, type STEPS in the comments below to join my free mini-course - 5 Steps To Improve Your Fertility Naturally, where I go into detail on each of the steps you can take to support your fertility cycle. 👇

#periods #periodhealth #naturalfertility #fertilitytips #fertilitydiet

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Jan 23

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Endometriosis can impact fertility and having a healthy pregnancy. 

Preparing ahead of time and taking the steps can make a big difference. 

Type ENDO in the comments below if you would like my natural guide to supporting your fertility regardless of having endometriosis....💛👇
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