Vitamin E Essential to Improve Fertility

Vitamin E Essential to Improve Fertility

Without vitamin E the body cannot reproduce. A study performed in 1922 showed that rats whose diet was devoid of vitamin E became infertile. Once they were given wheat germ oil (rich in vitamin E) as part of their diet, the rat’s fertility was restored. Today, research shows vitamin E is essential in protecting and improving cellular health. Each and every part of the body is made up of trillions of cells, including the reproductive organs, the egg and the sperm.

Alpha-tocopherol is the chemical name for the most active form of vitamin E. The term tocopherol comes from the Greek words tokos, which means “offspring,” and phero, which means “to bear”. Tocopherol literally means “to bear children”. Clearly vitamin E is essential to healthy fertility.

Primary Benefits of Vitamin E

Vitamin E functions primarily as an antioxidant, protecting cell membranes from oxidative damage. It has been shown especially effective for protecting nerve cells, red blood cells, and immune system function; aiding in the prevention of and healing of neurological disorders, chronic viral illness and anemia. Several studies have been performed in relation to fertility health, revealing its importance for reproductive function and health.

Vitamin E is incorporated into the lipid (fatty) part of the cell membrane, where it stabilizes and protects the cell membrane from toxic compounds including lead, mercury and other heavy metals; toxic compounds such as benzene, carbon tetrachloride, cleaning solvents (all known endocrine disruptors); medications; radiation; and free-radicals. This is especially important for hormonal balance, as well as cellular health. Toxic compounds have been shown to contribute to infertility.

Vitamin E deficiency is rare, but there are some conditions in which low levels are common:

  • Celiac disease
  • Cystic Fibrosis
  • Premature infants
  • Sickle cell anemia and similar red blood cell disorders
  • Fibrocystic breast disease

Increased Thickness For Thin Uterine Lining
A study published by Fertility and Sterility in April, 2010, showed that vitamin E supplementation may aid in increasing the thickness of the endometrium in women with thin uterine lining <8mm. Researchers wanted to see if these supplement could increase uterine radial artery (uRA) blood flow. Results showed vit. E given at 600mg a day increased uRA in 72% of patients and endometrial thickness (EM) in 52% of patients.

Improved Sperm Health and Motility, Reduction in Miscarriage
Studies have shown that vitamin E increases sperm health and motility. In one study it was shown that sperm motility, percent of live sperm, and percent of normal spermatozoa all increased with the supplementation of vitamin E and selenium.

As mentioned previously, a study performed on rats whose diet was devoid of vitamin E, showed those rats to become infertile. This study showed male rat’s sperm became immobile and female rats had a higher rate of miscarriages that rats who were not vitamin E deficient. The rats were then given wheat germ oil which is high in vitamin E and their fertility was completely restored.

Improved Glucose Metabolism and Insulin Activity for PCOS and Diabetes
Oxidative stress is a major concern for women who are trying to conceive and have either insulin resistant PCOS or diabetes. Vitamin E supplementation has been shown to improve insulin action. One study showed that non-insulin taking, otherwise healthy diabetics who took 1,310 IU of vitamin E for 4 months had improved glucose tolerance and insulin sensitivity. The researchers conclusion was that the vitamin E supplementation reduces oxidative stress, improving cell membrane physical characteristics and related activities in the transport of glucose. Speak with your doctor prior to using vitamin E at higher levels as part of a diabetes management plan.

Reduction in PMS Symptoms and Fibrocystic Breast Disease
Several double-blind clinical studies have been performed on vitamin E (alpha-tocopherol) supplementation for the reduction of fibrocystic breast disease and premenstrual syndrome (PMS). Premenstrual syndrome is cyclic and comes with many uncomfortable symptoms including, painful swelling of the breasts, bloating, water retention, cramping, headache, dizziness, foggy thinking, irritability and depression. Fibrocystic breast disease are benign tumors of the breast and often become painful and swollen with the onset of menstruation.

These studies indicate that women given 600 IU of vitamin E per day had a reduction in overall PMS symptoms, particularly fibrocystic breast disease. It appears the vitamin E normalizes hormone levels in both PMS and FBD patients.

Increased Success Rate for IVF
In another study, it has been shown that men who prepared with vitamin E prior to IVF treatment, with their partners, had an increase in rate of fertilization from 19% to 29%.

Miscarriage Prevention Support
Vitamin E in amounts up to 600 IU per day (use only 50 IU if you have high blood pressure, heart disease, or diabetes) has been shown to help prevent miscarriage in women with a history of recurrent miscarriage.

Supports a Healthy Amniotic Sac in Pregnancy
Vitamin E supplementation has been shown to help prevent premature rupture of the membranes (amniotic sac) in pregnancy. It appears that vitamin E may increase the quality of the amniotic sac.

Vitamin E Supplementation

First and foremost vitamin E should be consumed by eating a diet rich in a variety of different whole foods. Foods that are rich in vitamin E are: Raw vegetable oils, nuts, nut butters, rice bran oil, barley, seaweed, green leafy vegetables, asparagus, avocado, berries, and tomatoes.

As you learned before, vitamin E is an antioxidant. Antioxidants help protect protect the body from the damage caused by free radicals. Antioxidants neutralize the free radicals, stopping further damage from happening and protecting the cells health, but the body needs a variety of antioxidants to do this. Antioxidants work to stop free radicals by engulfing them, and then melding into its molecular structure. Antioxidants rely on other “sister” antioxidants to come and revive them, so they can continue on to stop free radicals from spreading and damaging cells. CoQ10, vitamin C and Lipoic Acid revive vitamin E. In order to be sure you are getting a wide variety of antioxidants, we suggest you supplement with a complete antioxidant supplement to protect cellular health.

There are a variety of different forms of vitamin E. If you choose to supplement with vitamin E, be sure you are first getting it through whole foods and second choose natural sources, never synthetic.

Natural Forms
d-alpha-tocopheryl acetate
d-alpha-tocopheryl succinate
Synthetic Forms
dl-alpha-tocopheryl acetate
dl-alpha-tocopheryl succinate

There are several other natural tocopherols that demonstrate vitamin E activity and exert antioxidant activity, they are: d-beta-, d-gamma-, d-delta-, and a group of related compounds known as tocotrienols. These are not as strong as d-alpha, but still beneficial.

Suggested daily usage: 500mg a day of mixed tocopherols and tocotrienols in addition to a diet rich in vitamin E foods.

1. Murray, Michael T., N.D. Encyclopedia of Nutritional Supplements The Essential Guide for Improving Your Health Naturally. Three Rivers Press, 1996
2. Takasaki A, Tamura H, Miwa I, Taketani T, Shimamura K, Sugino N (April 2010). “Endometrial growth and uterine blood flow: a pilot study for improving endometrial thickness in the patients with a thin endometrium”. Fertil. Steril. 93 (6): 1851–8. doi:10.1016/j.fertnstert.2008.12.062. PMID 19200982.


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  1. Is Vitamin E safe to take it you have Hashimoto’s? I noticed the bottle at Whole Foods said it contain soy. I typically do not eat anything with soy do to my thyroid. The person at Whole Foods said that all Vitamin E is derived from soy. Is this form safe for someone with thyroid issues or should it be avoided? Thank you!

    • Dear cslorraine,

      Vitamin E and Selenium are known to be two nutrients necessary to help the body properly convert thyroid hormones. Vitamin E is also known to play a role in healthy immune system function which may be supporting with immune-related health issues.

      Whether the supplement you mention is safe for you to use, I do not know. It would be best to speak with your healthcare provider about supplementing Vitamin E and with this specific product.

      Vitamin E is not only found in soy. If wishing to avoid soy and isolated nutrients from soy, consider searching for a new supplement and incorporation foods rich in vitamin E into your diet. There are many foods rich in vitamin E that can be added to ones diet, which include raw vegetable oils, wheat germ oil, nuts, nut butters, rice bran oil, barley, seaweed, green leafy vegetables, asparagus, avocado, berries, and tomatoes.

      We feel it is first and foremost important to eat a diet rich in vitamin and the supplement with a whole food vitamin supplement if needed.

      Take care!

  2. Is 1000iu of Vitamin E to much to take daily?

    • Dear Jaclyn,

      Vitamin E content of nutritional or dietary supplements is listed on a label in international units (IUs), a measure of biological activity rather than quantity which is measured in milligrams (mg). Conversion rules for naturally-sourced vitamin E (d-alpha-tocopherol) and synthetically-produced vitamin E (dl-alpha-tocopherol) are different.

      Suggested daily use of mixed tocopherols and tocotrienols in addition to a diet rich in vitamin E foods is 500mg per day. 1000IU of natural vitamin E would be 670mg and of synthetic vitamin E would be 450mg. So, unless be instructed to take 100IU of vitamin E by your healthcare provider, this may be a bit too much.

  3. Hello, am just wondering if it is safe to continue to take a Vitamin E supplement ( as well as Ubiquinol form of CoQ10 ) after ovulation if trying to conceive? Many Thanks

    • Hello Amy!

      CoQ10 Ubiquinol and Vitamin E can be taken all cycle long while trying to conceive. It is best to speak with your healthcare provider about taking them in pregnancy.