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How to Use Systemic Enzyme Therapy to Increase Your Fertility…

How to Use Systemic Enzyme Therapy to Increase Your Fertility…

What are Enzymes?

Occurring in every living thing on earth, enzymes are biological molecules that catalyze (increase the rate of) chemical reactions. Almost all chemical reactions in the cell need enzymes in order to occur at rates sufficient for life. They build new proteins, cells, tissues and organs, and also break down these same tissues.

The ability to ward off disease, repair injuries, and sustain the body’s homeostasis are all connected to the concentration and strength of enzymes we have in our bodies. There are over 3,000 different types of enzymes in the human body, constantly at work initiating millions of chemical reactions every second. If we did not have enzymes, there would be no digestion, no blood coagulation, no reproduction, no breathing, and no use of the senses. This gives you an idea of how important enzymes are for the body.

In the body, there are many different types of enzymes. We have all heard about digestive enzymes, which help us to digest our food, but there are enzymes that help with all the other functions of the body as well; these are called systemic enzymes. Systemic enzymes work on the entire system.

Benefits of Systemic Enzymes

Systemic enzymes have been shown beneficial for healthy fertility.

Systemic enzymes have been shown beneficial for healthy fertility.

Some of the beneficial actions systemic enzymes have within the body are to counteract chronic inflammation, reduce the substances in the blood that can trigger a hyper-autoimmune response, break down fibrin (the substance that scar tissue is made from), and improve blood flexibility and flow. All of these actions can help to support healthy reproductive function.

Anti-Inflammatory Effect
Systemic enzymes help to break down the substances in the blood that create inflammation and infection. This may benefit those experiencing chronic inflammation related to a fertility issue such as endometriosis, uterine fibroids, PID or ovarian cysts.

Chronic inflammation can be caused from and may cause injury to the healthy tissues of the reproductive system that are being invaded by foreign tissue or infection. Inflammation and foreign tissue growth can create scar tissue and adhesion formation in the reproductive organs and the surrounding structures within the abdominal cavity. Inflammation can also cause pain. Pain is a common problem for women with chronic inflammation due to fertility issues, especially endometriosis and uterine fibroids. Reducing inflammation with Systemic Enzyme Therapy may in turn help reduce pain.

Regulatory Effect on the Immune System
Systemic enzymes help the body to reduce the occurrence of a hyperimmune response. One study has shown that they may help to prevent the rejection of the fetus (recurrent miscarriage) and help with other issues related to reproductive immunological imbalances.

Systemic enzymes have also been shown to benefit autoimmune hypothyroidism – Hashimoto’s disease. One study noted that taking a systemic enzyme blend resulted in a reduction of autoimmune antibodies that attack the thyroid. Hypothyroidism can be a cause of infertility or recurrent miscarriages.

Breaks Down Scar Tissue
Systemic enzymes have the ability to break down fibrin, the substance that makes up scar tissue. Scar tissue and adhesions causing fertility issues can form for a variety of reasons, including uterine fibroids, pelvic surgery such as Cesarean Section, PID, damage to fallopian tubes, ovarian cysts, endometriosis, IUD, or abortion.

How systemic enzyme blends eliminate scar tissue:

  • The systemic enzyme blend works as a biological response modifier; working with the body’s own immune defense system to moderate the inflammatory response.
  • They support cleansing of the tissues and promote better circulation.
  • They break down and remove “fibrin”, the make-up of prolonged inflammation and scar tissue/adhesion formation.
  • They break down the proteins in the blood that cause inflammation; this facilitates their removal via the lymphatic and circulatory system.
  • They support a reduction in inflammation, an increase in proper blood formation, and an increase in circulation, which helps to hinder scar tissue and adhesion formation, while also reducing pain.

Improves Blood Flow

Systemic enzymes cleanse the blood, promote circulation, and stimulate the formation of new, healthy tissue.

Proteolytic enzymes improve blood flow by increasing the flexibility of red blood cells, inhibiting the aggregation of platelets, and helping to prevent abnormal blood clotting. Systemic enzymes also help to support cleansing of the tissues and promote better circulation as well as stimulate formation of new, healthy tissue. Simplified, they make the blood less “sticky”. This is beneficial for reproductive health in many ways.

The blood-cleansing actions of systemic enzymes help to bring proper circulation to the reproductive system and get the “stagnant blood” cleared out, helping to remove toxins and also bringing fresh, oxygenated blood to your uterus, ovaries, and eggs. Imbalances which are considered stagnant are endometriosis, PCOS, heavy dark menses, ovarian cysts, and uterine fibroids. The fresh, oxygenated, free-flowing blood is also able to transport more nutrients to the eggs, supporting egg health.

Types of Systemic Enzymes and Their Actions:

The benefits mentioned above have been validated through a variety of studies and clinical use on the following enzymes:

  • Serratiopeptidase (Serrapeptase) breaks down proteins, fibrin and mucus, to support the body in maintaining normal blood flow/circulation to the reproductive organs, aid in healthy fluid retention, and support a healthy inflammatory response.
  • Bromelain, extracted from the core and stem of the pineapple, breaks down protein and is beneficial as an anti-inflammatory.
  • Protease digests proteins to help improve the body’s immune system response to invaders; invaders are proteins in the form of fibrin which is the tissue that makes up a scar and some blood clots and contributes to Candida overgrowth.
  • Nattokinase enhances the body’s production of plasmin, the enzyme that dissolves and breaks down fibrin, to support healthy scar tissue formation by the body, while supporting heart health and healthy blood clotting.
  • Lipase breaks down fats for proper absorption in the intestines supporting the body’s ability to properly absorb fat which is very important for reproductive health, helps the body achieve optimal pH balance, and helps maintain a healthy weight.
  • Amylase breaks down carbohydrates, helping the body regulate glucose levels and achieve optimal ph balance, both necessary for healthy fertility; it promotes a healthy blood and environment within the female reproductive organs.
  • Papain, extracted from papaya, breaks down protein and is most beneficial as an anti-inflammatory.

These specific enzymes have been combined in a systemic enzyme blend formulated specifically for fertility; see it here…

Important note: Both amylase and lipase help improve the breakdown and absorption of food nutrients to free up pancreatic enzymes for boosting immune and inflammatory responses, and fight toxin buildup with the body.

Systemic Enzyme Therapy for Fertility

Systemic Enzyme Therapy is a natural method utilizing these unique enzymes to help support reproductive health and fertility. There are many fertility issues that may be supported with the use of systemic enzymes. Plan on using them for at least 3 months or more before you begin trying to get pregnant, depending on how long the issues have been around. Here are some of the issues systemic enzymes may help with:

Systemic Enzyme Therapy is one of the best and most effective natural therapies for endometriosis. Systemic enzymes may help to reduce scar tissue and break down the excess tissues left from endometriosis.

Systemic Enzyme Therapy may also aid women who have endometriosis by reducing the inflammation caused from the scar tissue irritating the surrounding organs and may help with the pain that sometimes comes from having endometriosis.

The blood-cleansing actions of this therapy help to bring proper circulation to the reproductive system and get the “stagnant blood” cleared out, bringing fresh oxygenated blood to your uterus and ovaries. For this reason, consider starting a natural fertility program for endometriosis with The Fertility Cleanse and, when that is complete, Systemic Enzyme Therapy and other natural therapies can be started.

For endometriosis it is suggested to stay on the Systemic Enzyme Therapy for at least three months prior to trying to get pregnant so all of the stagnant tissues and scar tissues can be cleared.

Recurrent Miscarriage
For recurrent pregnancy losses caused from either immunological response or blood clotting issues, Systemic Enzyme Therapy is an effective option. In a five-year study, women who had experienced recurrent miscarriage due to immunological response (more than 30% of miscarriages) were put on a systemic enzyme supplement before and during their pregnancies. 79% of the women carried out their pregnancies to term and gave birth to healthy babies. (Forum Immunologie, 2000) This is an amazing discovery. The only options available before this study were anti-immunological agents similar to the type used in transplant patients, but most doctors will not use them due to their toxicity during pregnancy.

If you have immune-related infertility and are interested in taking systemic enzymes into your pregnancy, talk to your healthcare provider and ask for guidance.

Uterine Fibroids and Cysts
Systemic enzymes have been shown in research to reduce the swelling and pain associated with fibrocystic conditions. They also help the body through its own mechanisms to reduce and eliminate cysts over time. With uterine fibroids, it is important to also make sure you are reducing your estrogen exposure and actively getting rid of excess estrogens; this can be done with the estrogen metabolizer, DIM.

Using Systemic Enzyme Therapy is one of the most important natural therapies for uterine fibroids. I have not found a more powerful way of reducing or supporting the body in eliminating uterine fibroids.

Old Scar Tissue and Blocked Fallopian Tubes
Systemic Enzyme Therapy can help to reduce the scar tissue, which may be affecting your reproductive system. Systemic enzymes eat away and reduce the formation of fibrin (the material that makes up scar tissue) over time, making this therapy extremely effective at reducing scar tissue.

Scar tissue and adhesions causing fertility issues can form for a variety of reasons: uterine fibroids, pelvic surgery such as Cesarean Section, PID, damage to fallopian tubes, ovarian cysts, endometriosis, IUD, D&C, or abortion.

Pelvic Inflammatory Disease
Systemic enzymes may be effective as medication at helping the body to overcome Pelvic Inflammatory Disease (PID). PID is a general term used to describe inflammation of the uterus, ovaries, and/or fallopian tubes. PID often comes from Sexually Transmitted Disease (STDs), and can be caused by parasitic, viral, fungal, and (most often) from bacterial infection. If left untreated, PID can lead to scar tissue and adhesion formation. If PID advances to this stage, it may lead to blocked fallopian tubes and sterility in women. Two thirds of women who have undergone laparoscopic surgery to determine infertility causation were found to have PID and were unaware they even had it.

A randomized, double-blind study was performed on 100 women with PID. One group was given 5 tablets of systemic enzymes three times a day. The control group was given an NSAID drug in the usual dosage. Both groups were also given antibiotics (PID requires antibiotics). The patients were given the treatment for 16 or 17 days. The systemic enzyme blend performed with amazing results in fighting damage to tissues, pain, inflammation and overall pelvic congestion. 57% of women using systemic enzymes were without any complaints, whereas only 6% of women who took NSAIDs were without complaints. Overall, 100% of the patients who used systemic enzymes reported their condition as substantially improved, compared to only 73.5% using the NSAIDs.

Supporting Egg Health
One of the major factors for increasing egg health is to increase the circulation to the ovaries. Systemic Enzyme Therapy can help to cleanse the blood, increase circulation, and make the blood less “sticky”. For best results use the Systemic Enzyme Therapy in conjunction with the OvaWise – Egg Health Program.

How to Use Systemic Enzymes

For the best results, you must take a high-quality systemic enzyme blend that contains the specific enzymes listed in the ‘Types of Enzymes’ list above. The one we feel is the best is the only fertility-specific enzyme product in existence, Fertilica Choice EnzymesTM.

Fertilica Choice EnzymesTM is specifically formulated to be a great ally for many fertility health issues using plant-sourced systemic enzymes in a vegetable-based enteric coating which ensures optimal absorption and utilization in the bloodstream.

Suggested Usage: Adults take three (3) tablets daily with water on an empty stomach. To ensure you have taken the tablets on an empty stomach, take Fertilica Choice EnzymesTM at least 45 minutes before meals, or 2 hours after eating a meal.

Take on an empty stomach: This is very important. The enzymes need to make it past the stomach to be absorbed in the intestine. Do not take with food. Wait at least 45 minutes before eating and 2 hours after eating to take your enzymes.

Safety & Side Effects

There has been no toxicity shown from using systemic enzymes. There is no dangerous or lethal dose of systemic enzymes. These enzymes are the same enzymes the body naturally produces. Fertilica Choice EnzymesTM can be used for preconception. Talk to your doctor about continuing any systemic enzyme blend throughout pregnancy (see above information) and do so only with the agreement/approval of your doctor.

Stop taking systemic enzymes two weeks prior to any type of surgery. It is best to begin use of systemic enzymes in preparation for conception for best results. If you are using systemic enzymes for possible miscarriage prevention, please talk with your doctor and get their approval for use during pregnancy.

Use During Pregnancy

Systemic enzymes can be used in preconception and have been shown to be helpful throughout pregnancy to help prevent recurrent miscarriage due to immunological imbalances (see study under Recurrent Miscarriage section) with the agreement/approval of your doctor. Please consult with your doctor or midwife before using any supplements during pregnancy.

Too learn more about related subjects covered in this article, please visit the following links:

Immune Infertility: Natural Options for Immunological Fertility Issues

How Hashimoto’s Thyroiditis Affects Fertility

Estrogen Fertility Guide

Serrapeptase for Fertility Issues

Our Complete Library of Fertility Issues



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  1. Avatar

    As the systemic enzymes break down proteins, would this still be advisable to continue during implantation and in the first 3 months of pregnancy after ivf? Couldn’t the enzymes possible breakdown the embryonic proteins?

    • Dear Joyce,

      Systemic enzymes can be considered in pregnancy with the support and guidance of a healthcare provider. Enzymes break down foreign proteins, invaders, those not naturally needed by the body for healthy function. They are not known to impact embryo health in a negative way. Systemic Enzyme Therapy using Wobenzym N has been studied in relationship to immune-related recurrent miscarriage and been proven helpful in some cases. Learn more about Wobenzym N here…

  2. Avatar

    I started to take the Wobenzym N but, had all the side effects from taking it. I am discontinuing using it. It was suggested to take Serrapeptase . Do you know of a reputable brand that I can use?

    • Dear Diane,

      I am sorry to hear this. There are many brands of enzymes available. We are not affiliated, but feel Enzymedica is a very high quality, reputable brand.

  3. Avatar

    I have a very large fibroid 19cm in the abdomen region. Some have calcified.
    Surgery is something i would like to avoid at all cost. Is there any natural way of shrinking the fibroids. If yes please advice step by step.
    Currently I am applying castrol packs basically everyday with 2 days off.
    I also have hypothyroid. Pls advice
    Thank you

    • Dear VJ,

      When fibroids have begun to calcify, it is commonly felt that the best first defense if surgery to remove the calcified growth after with a natural therapy program of prevention and to support uterine health could be considered. I share more and information about such a natural fertility program in our guide Uterine Fibroids in Pregnancy – Can Anything be Done Naturally?. Castor Oil Packs can be continued until a few days prior to a medical procedure to remove the fibroid.

  4. Avatar

    I have a question, and I am not sure if it has already been answered. I would like to know if it is beneficial to use Wobenzym N and Serrapeptase with Vitex to increase my chance of ovulation while working on unblocking my one and only tube? I am desperate and willing to try anything but I also do not want to risk my health by mixing herbs that may not go well together. Thank you in advance for your response.

  5. Avatar


    I had an hsg done a few weeks ago and it showed that I had proximal blockage due to scar tissue in both tubes the dye did not enter either of my tubes. My doctor said that there is little chance that surgery could fix anything but that my uturus looks like it is in excellent shape. I have 28 eggs and I was wondering which systemic enzymes you feel would help my situation. My husband and I have been trying to conceive for 9 years and I am wanting to learn more about the natural remedies if any to help with the issues I have been having. Do you have any suggestions?

    • Dear Charity,

      The enzyme blend we prefer for Systemic Enzyme Therapy is called Wobenzym N. Some have used either along or in combination with that an enzyme called Serrapeptase. Consider learning about them.

      The effectiveness of natural therapies depends on many factor. Our guide, Natural Therapies for Blocked Fallopian Tubes will share more about them, in addition to other natural therapies to consider learning more about.

      I hope this is helpful!

  6. Avatar

    Re: Rutin and pregnancy. Hello, would you happen to know the role Rutin plays in Wobenzym N? I have heard it can cause miscarriage, but I would be taking it to prevent it. I have a positive ANA (all other tests for antibodies normal) and have had 2 early miscarriages. My lining development is fine. I’m TTC and considering taking Wobenzym N during 1st trimester due to family history of autoimmune, as well as cardiovascular disease. I have not been able to find a doctor who would recommend it during pregnancy.

    • Dear Erin,

      The role that Rutin plays in Wobenzym N is as scavenger of free radicals. Rutin inhibits inflammation-producing enzymes within the body making it act as an anti-inflammatory agent as well.

      I have only every read of large or “mega doses” of Rutin potentially causing miscarriage. I have not seen clinical studies of this. I can ensure you that if the amount of Rutin in Wobenzym N came with even the slightest potential to impact pregnancy, it would not be suggested for use in pregnancy under the guidance of a healthcare provider by the product’s maker. If may also help to reach out to Garden of Life to ask their opinion.

      If it may help to share this article with a doctor if you feel strongly of its ability to help you in pregnancy. Feel free to do so.

      The tips in our guide 5 Steps To Decreasing the Chance of Recurrent Miscarriages may be helpful for you as well.

      Best wishes!

  7. Avatar

    I was looking at your website, I have uterine fibroids and done mayomctomy also. but it came back. i am single and 38 years old dont have kids. I am not looking any more surgery trying to find some other way to get rid of the fibroids. I heard about systemic enzyme therapy. I would like to know more about it and how soon it will start working to get shrink the fibroids. what items i have to take.

    • Dear Noren,

      I am sorry to hear the fibroids have regrown. Surgery can be so helpful for symptom relief, but sadly does not address the underlying hormonal imbalance causing them to grow. Thankfully there are herbs, nutritional supplements and natural therapies to support the body in maintaining a healthy environment within the uterus by promoting hormonal balance and supporting the body’s natural ability to reduce occurrences of occasional growths. Consider taking time to learn more from our guide The Best Natural Remedies for Uterine Fibroids…. We know that as important as taking any supplements, are dietary and lifestyle changes to reduce your exposure to excess estrogens. The guide just above shares more on this too.

  8. Avatar

    Hi, I found out during the removal of a uterine fibroid – that I have severe endometriosis. I have been doing the enzymes serrapeptase and wobenzym for one month. I am now experiencing a very light, brown discharge outside of my period and before my period. This has been happening on and off for the last two weeks. I have had this brown discharge (not flowing- just when I wipe) for 7 straight days. I don’t have any pain- in fact, I feel great!! I was wondering… Is the dark spotting a result of better blood flow? Is this normal? Should I be worried? Has anyone out there experienced this?

    I took a pregnancy test twice and no, sadly I am not pregnant.

    • Dear Aimee,

      I am so glad to hear you feel great!

      Brown spotting/blood is commonly old blood left over from the previous cycle. This may be caused by a sluggish menstrual flow, lack of uterine tone or low uterine circulation (or endometriosis or the fibroid removal depending on when that was). Herbs and therapies used traditionally for this imbalance are in fact, Systemic Enzyme Therapy, which you are using already, Self Fertility Massage, fertility cleansing, staying hydrated and possibly herbs.

      You may appreciate learning about the herbs we outline here in our guide 5 Steps to Reversing Endometriosis Infertility, as well as the dietary and lifestyle changes known to be helpful. There are also many resources here in our guide to The Best Natural Alternative Therapies for Endometriosis.

      Keep up the great work!

  9. Avatar

    I had an ectopic pregnancy November 2015. The dr said she is not sure what caused it. I had an std in 2006 but I had a healthy pregnancy and delivered in 2013. She said I have lesions but not sure if that caused it. My left tube (only tube left) is not blocked. I had an HSG in December 2015. I kept getting BV every month for over a year but I think it is finally gone away haven’t had it for a few months now. Could this help me and if so what kind/where do I purchase it. Thank you

    • Dear Stacy,

      As this guide shares, there are many fertility health benefits that systemic enzymes offer. They may be supportive.

      It may also be helpful to know that with one functioning, healthy fallopian tube conception may happen the months that ovulation occurs from the ovary on that side. Ovulation happens from one ovary one cycle and the other the next – the event alternates from side to side. So, knowing this, it is also going to be helpful to learn the tools available to help you detect ovulation (if you do not already do this) and these can be learned in our guide to Fertility Charting.

      We support using Wobenzym N for Systemic Enzyme Therapy. Wobenzym N is available from the Natural Fertility Shop.

  10. Avatar

    hello Doc, i just stumbled on this site, and I’m loving al i have read on the wobenzyme, please i would like to know if it can be used to treat PID since it really all about the pelvic areas, i really don’t understand why i am not getting pregnant. i went for a HSG and the dye didn’t flow from the right tube, plus i was told i had pelvic adhesions . i would like to start the enzymes right away.

  11. Avatar

    I have endometriosis and had a 7cm endometrian cyst diagnosed inside my right ovary 3 years ago. It shrunk to half the size through progesterone treatment but now it’s back up to 9cm and one doctor is saying surgery while another is saying supervision/control. I’m taking Vitex (Chasteberry), recently started with Milk Thistle (as I fear I may have a weak liver), vitamin C, calcium, magnesium and vitamin D supplements. I’m avoiding gluten, caffeine, dairy, red meat and non-organic poultry. Can systemic enzyme therapy be for me? I’m 35 and would like to prepare my body to conceive asap.

  12. Avatar

    Last year I had a d&c and since then I have had difficulty maintaining a thick uterine lining. I have been taking Wobenzyme for about a month now in hopes of helping decrease uterine scarring and increase uterine blood flow in preparation for another IVF cycle. MY RE just did a hysteroscopy to get a better look at what was going on with the lining and said that there was some scarring which he was able to remove but that also there were areas in the uterus that were not as vascular as it should be (from the d&c). My question is, I stopped taking the Wobenzyme about 3 days before surgery and now that the surgery is over, how soon can you resume use? Also, are they safe to take with Arganine?

  13. Avatar

    Thank you for all the information you provide, it is very helpful. I am diagnosed with endomitriosis and i have recently had laprriscopic surgery int November 2015 which was considered stage 1. I took the wobenzyme enzymes along with serapeptase 3 months before my surgery. I have also had 4 prior surgeries. I am currently trying to conceive. I also had a blocked tube in November 2015 and that was corrected during surgery. I would like to know if its ok to take serapeptase and wobenzymes at the same time of each other while having an empty stomach? also is it ok to take femara along with enzymes?

    • Hi Denisha,

      I am glad you find our information useful!

      Wobenzym N definitely should be taken on an empty stomach. It is best to follow the guideline of the manufacturer of the serrapeptase supplement you have chosen. These enzymes have a different action on the body than Femara, that being said, it is always best to let your healthcare provider know you are taking new nutritional supplements and just want to be sure it is okay with the medication.

      Best Wishes!

  14. Avatar

    Hello I’ve been taking Wobenzym N for about a month. I have RA and I’ve also had a tubal reversal. I’ve noticed this month during my period I’ve had way more clots than usual. They are huge. Is this due to the process of the enzymes removing scar tissue or is this a problem? I’m not having any pain at all and I usually have a very painful period just have the clots.

    • Dear Erica,

      It is not my experience or understanding that one would see any external evidence that systemic enzymes are working. They help the body dissolve fibrin and boost immune system function, etc. Clots are what forms when the body works to control excess bleeding. It may help to learn more about why they form and how the body can be supported naturally. I share this in our guide to Blood Clots During Your Period.

      I am glad your pain has gone away! That is a great sign!

  15. Avatar

    Hi, I had open myomectomy on 17 of Feb. Doctor removed 14 fibroids, had to make 3 small incisions on the back of uterus as well. Most of the myomas were intramural. I am 40, trying for the first baby, never pregnant until sept 2015 resulted an early miscarriage.
    Doctor planning to do IVF in 6+ month and said I can start trying for baby in 3 month.
    What can I do to maximize my chances to conceive naturally and with IVF and how to prevent the adhesions (particular diet, herbs, exercises, massage??). Not sure whether he put a barrier, it’s difficult here to communicate with doctors. I was home after 2 nights in hospital and the next visit to the doctor is in 3 month.
    Thank you.

    • Hello Nika!

      I hope recovery is going well and that you feel good!

      It is going to be important to address the underlying hormonal imbalance that led to the growth of the fibroids. Surgery removes then, but does not address the root cause. We offer suggestions for diet, exercise, natural therapies that does include Fertility Massage in our guide to The Best Natural Remedies for Uterine Fibroids… It is worth considering Systemic Enzyme Therapy as well (you will read that in the link I just shared as well).

      If by barrier, you mean an IUD, then rather than perform Fertility Massage at home, it would be best to consult a certified Mayan Abdominal Massage therapist and if that IUD is hormonal, we are required to suggest consulting a healthcare provider about taking herbs that have an action on hormones.

      It may be most helpful, that all being said, to have help in creating a program to help you naturally prepare for IVF. We offer this through a Natural Fertility Consultation if interested.

      All my best!

  16. Avatar

    I have had 3 ectopic pregnancies. the 1st resulted in a rupture on my left that damage my ovary and uterus. The other two had to be surgically removed from my right now. They were caught before a rupture. Could this product help heal my remaining tube? It has been 8 years since my last ectopic pregnancy; I have never been on birth control and have not been pregnant since the last ectopic pregnancy.

    • Hello Sara!

      I am so sorry for all you have gone through!

      Systemic Enzyme Therapy could be used alongside any type of treatment options you are considering, which may help to improve outcome. We know the ability of natural therapies in supporting normal fallopian tube health to be dependent on the severity of the damage. Fallopian tubes that are severely damaged need special care.

      Consider also learning about Mercier Therapy which is a deep pelvic organ manipulative technique to help restore movement and blood flow to the reproductive organs in order to improve fertility. Another alternative natural therapy is Clear Passages which you can learn about in the guide titled Natural Therapies for Blocked Fallopian Tubes.

      All my best!

  17. Avatar

    I read where you did not suggest taking systemic enzymes with an iud. The person who commented also had endo. I was told after a recent c section that I had thin uterine lining. I’m interested in possibly trying to have another baby in a couple of years and currently have an iud. If I don’t have any other known issues can I take the enzymes with the iud? I’ve had multiple c sections and would like to work on scar tissue concerns for as long as possible. Is there anything else that should be taken to thicken lining due to c sections?

    • Dear Kat,

      We can not suggest using Systemic Enzyme Therapy with an IUD regardless of any other fertility health issue(s). An IUD is foreign to the body and may cause adhesions, or the growth of fibrin (the tissue that makes up a scar) around where it is attached. Systemic enzymes are known to work to break down fibrin and could impact how the IUD is attached. Although we do not have proof of this, we can not suggest the combination of the two, even if there would be just a slight possibility of this happening.

      Exercise and herbs like Red Clover and Red Raspberry leaf to name only two of many, along with superfoods like Royal Jelly, Maca and Flax seeds may all offer support and can be used if the IUD does not contain hormones. Consider learning more in our guide Thin Lining of the Uterus: Build the Uterine Lining Naturally.

      All my best!

  18. Avatar

    Please help me, WHICH PRODUCT TO BUY. I have not had my periods in 1 year, the doctors say my uterine lining is not building up to have the periods, the lining is damaged from previous miscarriages and the removal of fibroids and cyst which i had. im so stressed as i really want to have a baby for my husband. Please advise me. i have read about the systemic enzymes and i really have hope.

    • Dear Mary,

      Thank you for reaching out to us!

      Learn the causes of a thin uterine lining and how to build it up naturally with a variety of natural therapies through this guide Build the Uterine Lining Naturally. There are several tips that can be used along with Systemic Enzyme Therapy.

      If you would like help with creating a natural fertility program focusing on uterine health and supporting the body in achieving balance so as to have a health period (that will include products to consider), please consider working one on one with a fertility herbalist through a Fertility Consultation.

      All my best!

  19. Avatar

    Is it ok to take Wobenzym while I’m also taking Radiant Wonder Clear Flow?

    • Dear Shilan,

      If the product Radiant Wonder Clear Flow is herbal, Wobenzym N can be taken with it. It may however be best to talk with the practitioner who suggested it to you about combining them.

  20. Avatar

    My hubby and I have been TTC for more than 2 years now. I just finished my 3rd failed IVF transfer and can’t bear to go through another round start to finish. The Dr. told me that he believes my IVFs failed due to Hydrosalpinx since my fallopian tubes are blocked (endometriosis and scar tissue from previous surgery). My question is can the Fertility Cleanse Kit be used along with the Wobenzyme to clear my tubes of blockages? I’ve already purchased and began using the Self-Fertility Massage DVD.


  21. Avatar

    I have had 3 miscarriages in the last 2 years. All were between 8-10 weeks after a healthy heartbeat on ultrasound. I have 2 healthy children that we had before my miscarriages. After my son was born, who is now 4, I had to have 2 d&c’s for retained placenta and was in the hospital after the 2nd d&c because of infection and a small uterine perforation. My husband and I have had all the work up other than nk cells and some other immunology stuff. The only abnormality is that I have one blocked fallopian tube, but I have gotten pregnant twice since that diagnosis. My question is, do you think it would be beneficial to take wobenzyme? Thank you.

    • Dear Danita,

      I am very sorry for your losses!

      Wobenzym N is a blend of systemic enzymes that helps to support the body’s ability to break down fibrin (the substance that makes up scar tissue), natural inflammation response – providing relief for occasional discomfort in the reproductive system and its natural ability to reduce tissue buildup in the uterus – normal immunological response, as well as to encourage normal circulation to the reproductive system.

      It could be considered if you feel these benefits fit your needs. There may be additional tips in our guide to Decreasing the Chance of Recurrent Miscarriages as well.

      I wish you well!

  22. Avatar

    Does your enzyme therapy do a similar thing to Serrapeptase? For some unknown reason my stomach cant handle serrapeptase, and it makes me nauseous. Keen to try these enzymes instead and see how they go! Can serrapeptase be taken with these enzymes?
    Will these enzymes do anything if taken with food? Just seems to be a better option for a sensitive stomach!

    • Dear Sarah,

      Wobenzym N, the enzyme blend we suggest for Systemic Enzyme Therapy for fertility, can be combined with Serrapeptase. We have a guide to help you learn how to know if Serrapeptase enzyme therapy is right for your fertility issues and to share the research on the effectiveness of Serrapeptase for fertility health. I hope that is helpful!

      Systemic enzymes are best taken on an empty stomach either at least 45 minutes prior to eating or 2 hours after eating. Systemic enzymes need to be taken on an empty stomach and enteric coated to bypass the acidic stomach environment to enter the gastroinestinal tract where they are able to be digested, absorbed and assist the metabolic functions of the body, for example support repair of tissue damage, a reduction in inflammation, breakdown of fibrin, etc.

  23. Avatar

    I had a surgery for Polyp removal last week and still have some pain today and am looking for a solution for the best repair of the lining – I am in an IVF process and planning to have a embryo transfer, normally at my next cycle – Would you advise the treatment in this situation and one week after surgery? Thanks!

  24. Avatar

    My tubes are blocked and the HSG could not see well all my tubes though no abnormal growth found. Would like to try Wobenzym N. After delivery of my daughter through CS i got an infection which took three months to heal the cut. Because of this the doctor advised i take family planing pills that is normally given after birth but before i finished the first months pills they triggered my blood pressure. Since then my b.p could only be controlled by the high pantessive pills. Im currently on Nilol tabs that i take once daily (evening). Im just wondering if i can go through this natural process with my case of high pantessive. are the any side effects???? Kindly advise

    • Dear Dorothy,

      Wobenzym N is not to be taken without consulting your doctor if you are on medications including those for blood pressure regulation, blood thinners or other NSAID prescribed therapy. Please consult your healthcare provider if wanting to try Wobenzym N.

      Consider also learning about the alternative natural therapy Mercier Therapy, which is a deep pelvic organ manipulative technique to help restore movement and blood flow to the reproductive organs in order to improve fertility. Another alternative natural therapy is Clear Passages which you can read about here… Natural therapies can often be used in combination with medications and may be helpful when herbs and supplements should be avoided.

      I hope this is helpful!

  25. Avatar

    Would you recommend using serrapeptase and nattokinase during ivf cycle in which they noticed endometriomas? My RE told me that they are small and “not producing estrogen” but I would like them gone so they do not create issues down the line.

    • Hi Paula,

      It would be best to run this question past your doctor first. Your doctor may or may not feel comfortable with you taking them around the time of harvest or embryo transfer. Endometriosis is complex and enzymes alone may not be all to consider when wanting to support the body in naturally getting rid of it. Those enzymes help the body mediate immune system and inflammation response, which may be useful for women with endometriosis. At this point, being so close to your IVF cycle, it may be best to just focus on ways to help your body be more receptive of pregnancy, rather than “treating” the endometriomas.

      May your IVF be successful!

  26. Avatar

    Hello, can Wobenzym be taken for endometriosis and C-section scarring whilst breastfeeding?

  27. Avatar

    Was diagnosed stage 3 Endo in 2011 when I had laproscopy to open both tubes which were both 100% blocked. Endo was treated with 3 months of Lupron followed by 3 months of Clomed. Nov 2013 I had Mercier therapy. I just had another HSG test which concluded both tubes are 100% blocked again (appears to be proximal blockage). I am not too excited about another surgery and forced hormones. Would this be an option to help naturally clear my tubes and clean up the endometriosis?

    • Dear Hannah,

      Systemic Enzyme Therapy may be included in a program to address these issues. Consider learning why and also how to consider naturally supporting the body’s natural ability to remove excess estrogen from the body, in maintaining its natural inflammatory response, providing it relief from occasional discomfort in the reproductive system and encouraging normal circulation, helping to bring fresh blood and oxygen to the reproductive system all of which benefits each reproductive organ in the articles 5 Steps to Reversing Endometriosis Infertility and Natural Therapies for Blocked Fallopian Tubes.

  28. Avatar

    I have been trying to conceive for about 2 years. I have one kid (5 years) and had a miscarriage 2 years ago. After the miscarriage, I have noticed my periods are like dark brown for first two days and very thick blood, just want to mention here I was also diagnosed polycythemia vera (very high platelets count) after my first pregnancy and I am taking baby aspirin after then. So, is it safe for me to take Wobenzym N and do a Fertility Cleanse? My gynaecologist has checked everything like hormones and for PCOS, all clear. I have no issues, but just high platelets count. Please advise.

    • Dear Bia,

      I am very sorry for your loss!

      We can not suggest taking Wobenzym N or doing a Fertility Cleanse while taking baby aspirin unless being guided in doing so by your healthcare provider. Consider talking with him/her about your interest in Systemic Enzyme Therapy.

  29. Avatar

    I have severe Adenomyosis and a few small fibroids. MDs recommend complete hysterectomy due to multiple hospitalizations, etc. (I know it’s crazy but it’s not my wish). Can both Serrapeptase and Wobenzym N be used at the same time? Thank you.

  30. Avatar

    Hi! Is it okay to take Wobenzym N after ovulation if trying to conceive?

    • Dear Suzanna,

      Wobenzym N can be taken all cycle long and should be discontinued upon first determination of pregnancy although it has been shown safe for use in pregnancy under the supervision of a healthcare provider/doctor.

  31. Avatar

    Hi, I was wondering if this will work for me since I was diagnosed with cysts on both my ovaries. I have pain on left side after menstruation. Currently I am taking DIM, vitex, vitamin E 400mg, and other vitamins. Also, every day drinking apple cider vinegar, adding this to my regimen will help because currently I am in pain!

  32. Avatar

    I and my colleagues have learned much, much more from this source of information.

  33. Avatar

    I have Hashimoto’s and Graves Disease and was wondering if you have heard of anyone taking the enzymes with Graves Disease?

    • Dear Janae,

      We have a number of clients with autoimmune-related fertility health issues who have considered or used Systemic Enzyme Therapy. This natural therapy is used to support the body in having a healthy inflammation response in a variety of disease states. It is thought that reducing inflammation may help the body to not have unnecessary immune reactions.

      The article How Hashimoto’s Thyroiditis Affects Fertility may offer helpful considerations to make when creating a natural fertility program. Know that if wishing for guidance with this, our fertility herbalist is happy to help you. She offers this through a Fertility Consultation.

  34. Avatar

    I recently suffered a missed miscarriage which required 2 d&c within 2 weeks to fully remove the miscarriage. During the 2nd d&c my uterus had a small perforation from the procedure. I am very concerned about uterine scarring from the two procedures and was placed on estrogen patches for one month to minimize scarring. I also have Hashimotos and my thyroid numbers indicate I went hyperthyroid after the miscarriage and my antibodies are actively attacking the gland again. I was in remission until the pregnancy and miscarriage. Is it ok to take Wobenzym this soon after a d&c to help prevent scarring and lessen the autoimmune attack on my thyroid, or should I wait for the uterus to heal?

    • Dear LB,

      I am sorry for your loss!

      Systemic Enzyme Therapy is something we suggest for post-procedure healing. It can be started after bleeding has stopped post D&C and may help to prevent scar tissue from forming.

  35. Avatar

    Just concluded a fertility cleanse with the onset of a new cycle. I bought Wobenzym N, extra Women’s Best Friend and DIM. Can I continue to take all products mentioned in addition to those left over from the fertility cleanse? I was diagnosed of endometriosis and have read through your sight, hence the choice of products mentioned. I am doing fertility massage and Castor Oil Packs, and drinking fertility smoothies as well.

    • Dear Liz,

      Wobenzyn N, DIM, fertility massage, Castor Oil Packs and Fertility Smoothies can all be combined together and with the leftover Fertility Cleanse Products. If there is Women’s Best Friend left from the Fertility Cleanse it should finished before starting the “extra” purchased (don’t double up the dose).

  36. Avatar

    I have a history of fair amount of endo with surgeries, removal of one ovary/tube, ovarian cysts (most recently looking polycystic…I’m underweight), adhesions, and my other tube spills but is fairly dilated. I am likely getting ready to try Clomid in hopes of producing multiple eggs with the hope that at least one will make it through my tube and “survive” the hostile environment that is my reproductive system 🙂 but worried about the risk of more cysts. Now I’m thinking about trying something natural first, even if to prep for Clomid. **Can one take the Systemic Enzyme Therapy WITH the Fertility Cleanse at the same time (maybe throw in some massage and castor oil packs, but NO Clomid)

    • Dear A.,

      Systemic Enzyme Therapy can be combined with the Fertility Cleanse, Fertility Massage (consider doing this with Radiant Womb Massage Oil) and Castor Oil Therapy. As you have read it offers a variety of fertility health benefits.

      There are Many Faces of Polycystic Ovarian Syndrome. There are also a variety of ways to support body’s natural ability to remove excess estrogen from the body, in maintaining its natural inflammatory response, providing it relief from occasional discomfort in the reproductive system and encouraging normal circulation, helping to bring fresh blood and oxygen to the reproductive system – all important when dealing with Endometriosis Infertility.

      All my best!

  37. Avatar

    Please list your sources of enzymes. I am a vegan. I do not want to eat enzymes derived from other animals.

    • Dear Ian,

      I can share with you that the enzyme blend used in Systemic Enzyme Therapy called Wobenzym N does contain enzymes from animal sources. This products would not be suited for a vegan.

      So you know, the enzyme sources are listed on the product information page at the Natural Fertility Shop.

  38. Avatar

    I read about an enzyme produced by a silkworm called Serrapeptase. What are your thoughts about this particular enzyme?

  39. Avatar

    Im currently taking wobenzym n, can I continue this throughout pregnancy. I see comment below that it should be discontinued once pregnant. please advise. thanks

    • Dear Nina,

      We can not suggest taking Wobenzym N in pregnancy. Consider talking to your healthcare provider about taking it in pregnancy if you wish to do so. It is best to be guided in doing so by him/her.

  40. Avatar

    Hello. Thank you for your very informative website. I have stage IV endometriosis and would like to try Wobenzym N. Can I continue taking Wobenzym N while trying for pregnancy? If not, how long before trying for conceiving one should stop taking this medication? Thank you

    • Dear Fate,

      I am happy our site has been informative!

      Wobenzym N can be taken while trying to conceive. It can be discontinued if you think you are pregnant or upon first determination of pregnancy.

  41. Avatar

    I recently discovered a hydrosalpinx to the dx tube. The the sx one wasn’t clear if it was blocked or the dye didn’t have enough pressure to go all the way up. My healthcare provider wants me to have surgery to remove the dx tube and check the sx one, and potentially remove that one if she finds liquid in it. I feel this is an extreme way to proceed and I’m not happy at the thought of removing my tubes. So, I was researching alternative ways and I came across your website. How do I actually start this supplement and know if it would help me? Thank you!

    • Dear Silvia,

      Systemic Enzyme Therapy using Wobenzym N can be started at any time in the menstrual cycle and used all cycle long unless experiencing heavy menstrual bleeding, in which case it should not be used during menstruation. The article Natural Therapies for Blocked Fallopian Tubes may offer additional information and insight into whether this may be a natural therapy for you. It also shares additional considerations to make.

      All my best!

  42. Avatar

    Worried about an immune response as I have had endometriomas and an ovary removed and then had 2 miscarriages. After a failed IVF cycle I developed a severe case of
    hives. Can Wobenzym be taking through an IVF cycle to prevent an immune response?

  43. Avatar

    Hi! I have suffered 1 miscarriage and 3 IVF failures. I’m interested with the Fertility Enzyme Therapy. Where can I purchase Wobenzym N? Can I order it from you? Thanks!

  44. Avatar

    Hello…I have been recently diagnosed with Adenomyosis, fibroid cysts and hypothyroidism. I had two C-Sections and one tubal pregnancy, all in my early 20s. After my last child was born I had my tubes tied/burned. I cannot afford to take off work for a Hysterectomy. I am researching alternative methods to help me with the continuous back pain/cramping that I have as well as the 7 day long clotted periods that sometimes occur twice a month. I am almost 48 and pretty healthy overall, except for this. Any advice?

    Thank you
    Have a nice day

  45. Avatar

    I am 1 wk postpartum after delivering my 3rd child via c-section. I had all three children by c-section. With this last operation, I also got my tubes cut, tied, burned. We do not want any more children. When the doctor opened me up, he found massive scaring. He made reference to possibility of longer, painful periods. And that if it persists, hysterectomy may be needed due to adenomyosis. I am 34 with no health problems. I was one birth control pills for 5 years and stopped it in 2010. No issues with my periods. My main goal is to restore healthy function and reduce adhesion after this c-section. Is wobenzym and castor oil pack the best way to approach my healing?

    • Dear See,

      Congratulations on the birth of your baby!

      Systemic Enzyme Therapy using Wobenzym N and Castor Oil Therapy may be supportive. Wobenzym N is known to support the body’s ability to break down fibrin, encourage normal circulation to the reproductive system and help to maintain normal immunological and inflammation response in the body. Castor Oil Therapy also encourages mild detoxification and normal circulation to the reproductive system.

      It will be best to wait to begin any program to support reproductive system health until you have healed from the c-section. Castor Oil should not be applied on incisions until they are fully healed.

      Adenomyosis is rare, but consider also learning more in our article Adenomyosis: Causes, Risks, & Natural Healing Options.

      All my best to you! Again, Congratulations!

  46. Avatar

    I have stage III endometriosis and have a Mirena IUD inserted to control bleeding and attempt to preserve my fertility. Would enzyme treatments be beneficial now? Or would it best to wait until after I have the IUD removed and am actively trying to conceive, possibly after another surgery.

    • Dear Rebecca,

      Systemic Enzyme Therapy may not be the best at to use at this time. It would be best to wait to begin this therapy until the IUD is removed. Also know that one should stop taking systemic enzymes two weeks prior to any type of surgery.

      Other alternative natural therapies to consider when you no longer have an IUD could also include Mercier Therapy and Castor Oil Therapy with out heat.

      All my best!

  47. Avatar

    How does one find practitioners who provide these kinds of services?

    • Dear JLeeM,

      Systemic Enzyme Therapy is actually a supplement you take rather than a “therapy” that one would partake in with a practitioner. We do have a fertility herbalist on staff who works one on one with clients though. Learn more about Fertility Consultations here…

    • Avatar

      I have uterine fibroids which have grown bigger since having the Miren, but I love the fact I am no longer anemic and can live a normal life. My periods were so painful and heavy it impacted on my life for years. I tried for years with herbal/Chinese/homeopathic/yoga everything to stop it, but eventually gave in and had the Mirena inserted and after the initial 6 months of my body adjusting, I was just so happy. I don’t want it removed, but I am becoming increasingly uncomfortable in the abdomen. Can I take systemic enzymes while still having the IUD in.


    • Dear Bill,

      Systemic Enzyme Therapy is not suggested while an IUD is in place. Consider learning how to naturally reduce exposure to xenoestrogens and promote healthy estrogen metabolism through diet. There are few natural therapies or herbs we can suggest with hormonal birth control like the IUD.

      All my best!

  48. Avatar

    This was very helpful thank you!

    • Avatar

      How to help with someone who been diagnosed with Premature Ovarian Failure?

    • Dear Lynn,

      There are two ways we can support you. We can link you to information to help you learn what may cause premature ovarian failure (POF) to happen and what can be done about it. Our guide Understanding Premature Ovarian Failure will help you do that. We can also work one on one with you through a Fertility Consultation. This allows our fertility herbalist to guide you in the right direction, on the right program, for your specific fertility health needs.

      Thank you for reaching out to us!

  49. Avatar

    Hi! I have pain right now and I think its my ovary again… I haven’t had my trans-vaginal ultrasound yet, but I know this is my problem again.

    I have medication allergies, like to Ladogal. My doctor gave it to me for my cysts before
    then changed it to Duphaston which is fine with me. Do you think if I take this there will be
    no more allergic reaction to my body?


  50. Avatar

    I am a 40 yo woman who has had 2 abortions, a miscarriage and now an ectopic pregnancy. All activity was prior to ectopic pregnancy with my husband just recently. I have no medical conditions. No diseases or complications. I had an HSG which was normal. My husband is 34 and also has no complications. I have taken Birth control most of my life. Is it possible to still conceive? We were devastated by what happened. I was about 6 weeks when we found out that the baby was not in the uterus. I also now believe that the fertility drugs caused me to have an ectopic pregnancy which my fertility doctor prescribed. Help! How do we move forward? I’m scared to take fertility drugs now. They gave me methotrexate and it didn’t work, so I had to have surgery to remove baby. Any advise would be helpful!