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Interactions Between Fertility Herbs & Medications

Interactions Between Fertility Herbs & Medications

Did you know that there can be interactions between fertility herbs and medications? Are you someone who is currently taking fertility medications, but desire to try a more natural approach to healing your fertility issues? Before you embark on a natural fertility health plan, wouldn’t it be helpful to know if it is safe to combine fertility medications with herbs and supplements for fertility?

Perhaps you are frustrated with your natural fertility journey, about ready to give up, you are considering trying out some fertility medications, but are unsure if it is safe to continue on with natural remedies you are currently taking. Maybe the worry is that prescription medications you are taking for other health conditions, may interact with herbs for fertility. Is it really safe to combine medications with herbs? How can you make smart choices regarding your fertility while you are taking prescribed medications? I hope to cover all those topics for you, providing information on popular fertility medications and their possible drug interactions.

Video: Interactions Between Fertility Herbs & Medications

Natural remedies are often sought out once health problems feel out-of-control, after we have tried medications and nothing our doctor prescribes is working. It’s not surprising that natural remedies are not the first thing that comes to mind in our society. We don’t really see ads sharing the benefits of an herbal remedy on TV. But just about every other commercial is about some sort of ailment and the medication that can help you with that problem. You know the ads, the ones with the 30 second blurp at the end about the numerous side effects of using the medication, spoken so quickly and quietly you can barely make out what they are saying. In 2004, the Center for Disease Control released its findings on how many prescription drugs the average American was taking. The number is 12 per person in America. That is a lot of medications.

Making Smart Choices When Combining Fertility Herbs with Medications

I already take medications for fertility, is it okay to take herbs for fertility?
We never suggest combining herbs for fertility with medications for fertility. This is because most herbs for fertility, have the ability to affect key hormones without actually containing hormones themselves. Because of this, herbs for fertility have the potential to affect how fertility medications are working in your body. Usually when a person has chosen to take a fertility medication, they are investing a lot of thought, time and commitment to the treatment, as well as sometimes a lot of money. There is a lot of emotion and hopes riding on the choice of using the medications; the hope of getting pregnant.

Would you want to risk your chances of conception by possibly messing up how the drugs you are taking are working in your body? This is especially important when considering IVF. It is never a good idea to take fertility herbs once you begin your medications for IVF. Taking fertility herbs while you are taking medications for IVF may alter the outcome of your IVF. It would be very disappointing to possibly affect your ability to become pregnant. Prepare in advance of taking medications for fertility. Make a natural fertility plan, at least 3-6 months before beginning medications for fertility.

If you want to take herbs for fertility, wait at least a couple of weeks to one month after discontinuing the medications, before beginning your natural health plan. This will give your body some time to cleanse the medication from your system. Fertility Cleansing may also aid your body in additional cleansing of excess hormones.

This information applies to birth control as well. If you are on birth control, we do not suggest using herbs for fertility, as they may affect how the birth control works, which may lead to an unwanted pregnancy.

Is it okay to begin fertility medications like Clomid or Provera while continuing my herbs for fertility?
No. We do not recommend using any herbs for fertility during a fertility medication cycle. A cycle is about one month, or one menstrual cycle. Even if you are using a fertility medication for only one part of your cycle, we do not suggest using any herbs for fertility during other times in that same cycle.

Plan ahead. If you are thinking of starting a fertility medication, make your doctor appointment for about a month after weaning yourself off of the herbs you are taking. Continuing a multivitamin would be fine.

Can I combine fertility herbs with my medications for my other health problems? For example: heart, cholesterol, thyroid, diabetes, seizure medications.
This really depends on the medication you are on, and what fertility herb you are interested in taking. Because doctors are not usually familiar with herbs and herbalists are not familiar with medications, it can be difficult to find the answer. It is important to have open communication with your doctor, let them know the herbs you are interested in, as well as any supplements. Ask them their opinion. Do your own research. Search out an herbalist in your area if need be. Doing your homework before hand will help you to avoid an adverse reaction between the two.

Many times you will come to find that it is fine to continue on with some herbs and supplements for fertility, while also continuing your medications.

Can I take fertility herbs while also using Medical Marijuana?
There are no known interactions with fertility herbs and medical marijuana.

Fertility Herbs and Known Medication Interactions

The following is a list of common fertility herbs and known medications that they may react negatively with. This list is not complete and new information is surfacing each year. This is meant to be used for general information. Please always check with your doctor prior to beginning any herbs or supplements if you take prescription medications or over-the-counter medications regularly. The interactions may mean they exacerbate the effectiveness of the medication, or inhibit/reduce its action.

Black Cohosh (Actaea racemosa)
*Estrogens, oral contraceptives, antihyperlipidemics (lipid lowering drugs).

Borage Oil (Borago officinalis)
*Anxiolytics (anxiety drugs), anticoagulants (blood thinning drugs).

Dong Quai (Angelica sinensis)
*Anticoagulants, estrogens, calcium channel blockers, beta-blockers, antiarrythmics.

Evening Primrose Oil (Oenothera biennis)
*Phenothiazines (found in many antipsychotics, antihistamines), anticonvulsants (seizure), NSAID’s, corticosteroids (steroid hormones), beta-blockers (heart med.), anticoagulants.

Ginkgo (Ginkgo biloba)
*Anticoagulant, antiplatelet, anticonvulsants, antidepressants

Ginseng (Panax ginseng)
*Hypoglycemics, diuretics, Digoxin (digitalis heart med.), antidepressants, anticoagulants, estrogens, corticosteroids, calcium channel blockers, cardiac glycocides, methyldopa, phenothiazines, spironolactone.

Licorice Rt. (Glycyrrhiza glabra)
*Spironolactone (antidiuretic, antiandrogen), cardiac glycosides, thiazide diuretics, corticosteroids, cyclosporine (immunosuppressant, organ transplant) , monoamine oxidase inhibitors (MAOIs for short, antidepressant), oral contraceptives, hormone replacement therapy (HRT).

Red Clover (Trifolium pratense)

Saw Palmetto (Serenoa repens)
*Prescripton iron, estrogens

Seaweeds, especially kelp, wakame
*Thyroid hormones

Siberian Ginseng (Elutherococcus senticosis)
*Digitalis (heart med.)

Vitex (Vitex agnus-castus)
*Dopamine receptor antagonists

Fertility Supplements and Known Medication Interactions

Systemic Enzyme Therapy
*Anticoagulants, heart medications, NSAID’s.

*Heart medications,erectile dysfunction medications.

*Thyroid medications, anticonvulsants.

Natural Progesterone Cream
*Prometrium (snythetic progesterone, may compete for receptor sites, create too much progesterone in the body), oral contraceptives, HRT.

It is Better to be Safe Than Sorry

Be sure that you are planning ahead. Prior to taking medications for fertility, medications for existing health issues, or herbs for fertility, talk to your health care provider. You would not mix or combine medications without first consulting your doctor/naturopath, be sure you do the same with herbs and supplements.

Here are some safety tips…
1. Research herbs you are interested in thoroughly, prior to use. Ask your doctor, naturopath or local herbalist questions prior to beginning herbs for fertility.
2. Make a 3-6 month plan, write it down. Include medications you are currently taking, medications you are considering, and herbs/supplements you are taking or are interested in.
3. Never combine herbs for fertility with medications for fertility.
4. Give your body a 2 week-1 month break between fertility medication use and fertility herb use.
5. Do not exceed suggested dosage for herbs, the same goes for medications as well.


  • Romm, A. J. (2010). Botanical medicine for womens health. St. Louis, MO: Elsevier.
  • U of M health system providers. (n.d.). University of Michigan Health System – Basic list of drug-herb interations. Retrieved from

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  1. Hello, thank you for the article and video.
    What herbs/supplements interact with Clomid? I am going to start taking it when I get my next period (c.14-21 days away). I think DongQuai and Vitex are the main ones so as of today I have stopped Vitex & tomorrow dongquai.
    I take Maca, dongquai, oil evening primrose, l-ariginine, CO-Q10, Shatavari, Tribulus, Royal Jelly, Bee Pollen, vitamin B complex, zinc, brown seaweed, spirulina, super green, vitamin d, folic acid.
    Please will you tell me which of these I can keep taking? I have researched and think that zinc, folic acid, vitamin B&D, CO-Q10, super greens are fine but the rest I am not sure about. Please will you help?
    Thank you so much 🙂

    • Dear Natasha,

      We’re grateful this has been helpful! It is best not to combine herbs with Clomid, including Royal Jelly and Evening Primrose Oil. So, unless your doctor suggests otherwise, we have to suggest stopping Maca, Vitex, Dong Quai, Tribulus, Shatavari and Royal Jelly and Evening Primrose Oil. Herbs and supplements that act on the hormonal system could affect how your medications are working. It is best to only use herbs in preparation beforehand and not mix the two.

  2. Hi, I am taking 25 mg hypothyroid medication . My doctor does not have any idea of fertility cleanse. She was not helpful to answer my question. Can I do fertility cleanse and take my thyroid pill at the same time?

  3. Hi, I just started taking Letrozole, and also take Rhodiola to lower cortisol. I stopped taking all of my herbs that might effect hormones, namely Maca & Rhodiola, but I am wondering if I can continue taking Rhodiola?

  4. I would like to know if the herbs I am taking are all safe to take together. Royal Jelly, Vitex Berry, Dong Quai root, Red Clover, Raspberry Leaf, and a whole food prenatal vitamin. I had a pregnancy in October that resulted in a miscarriage at 10 weeks. I am getting my body back in shape for another try in June. I have been taking these all together since January. I haven’t had any bad effects but I just wanted to make sure.

    Thank you

  5. I am currently on Northendrone to suppress my stage 4 endometriosis. Can I do the fertility cleanse while on this medication. If I can’t, what are the reasons?

    • Elizabeth Willett, MA, CH

      Dear Nichol,
      We do not advise doing a Fertility Cleanse if you are currently already on fertility medications (including birth control) or undergoing a procedure. You should not combine herbs with your medications. Herbs that act on the hormonal system could affect how your medications are working.

  6. Update 2014 – We are back! We have been away for a while and we sure have missed all of your wonderful questions and thoughts on our articles. Moving forward, one of our staff herbalists will be here to respond to comments! We look forward to connecting with our readers once again!

  7. Can I take Prometrium (progesterone drug) while taking Maca, Wobenzyme, and Thyrophem, for fertility? I have low progesterone and my doctor does not want me using the progesterone creams because she says they are hard to measure and she wants to ensure I am getting the right dosage.

  8. This is really useful. Do you happen to know of any interactions between fertility herbs and drugs for Rheumatoid Arthritis? I’m not sure of the herbs, my herbalist’s English is very poor so sorry I can’t be specific. I’m assuming they’re the common ones listed above. The RA drugs I’m on are salazopyrin, predisone, plaquenil and Enbrel injection.

  9. Hi,

    I recently ordered a male and female fertility cleanse but there aren’t any instructions on what kind of foods to avoid? and what foods are best to take during the cleanse?. Please advise

    I take allergy tablets citrizine chloride every other day as I suffer from Idiopathic Urticaria, can i still use the fertility cleanse.

    Kind Regards

  10. Hi .First I tell you that this is my favorite website. Can i take the candida detox and bio-5 probiotic blend with levothyroxine, omega3, evening primrose oil, flax seed oil, multivitamins, antioxidants and Aciclovir. Thank you.

    • Hi Jay,

      I am glad you like the website! Candida Detox is fine to take with probiotics, omega-3, EPO, flax seed, a multivitamin and antioxidants, but you would need your doctors approval to use it with levothyroxine and Aciclovir. We are not medical doctors and we are not qualified to suggest using herbal blends for use with your medications. Candida Detox has many herbs in it, which may or may not be safe with your medications. Please speak with your doctor about this.

      Best Wishes,


  11. hello,can i take folic acid with fertility cleansing.