Natural Progesterone Cream Use: 10 Things You Should Know

Natural Progesterone Cream Use: 10 Things You Should Know

Every woman who is considering, or is already using natural progesterone cream should know these 10 important tidbits of information about this bio-identical hormone cream. We find many women use the cream incorrectly, or are worried about how they are using it. The more you know about natural progesterone cream, the better able you will be able to support your progesterone levels correctly.

1. Apply natural progesterone cream correctly. If you are not applying it correctly it may not be effective. The best areas for application are places in which capillaries are dense and close to the surface of the skin, such as:

  • Face
  • Neck
  • Upper Chest
  • Breasts
  • Inner arms
  • Palms of hands and feet

Avoid putting NPC on the fattiest areas of the body, as this may inhibit proper absorption. Fat will store the progesterone, rather than allow it to move into the bloodstream, circulate and be utilized by the body. In addition, rotate where you apply the cream each time you use it to avoid saturation.

2. Estrogen dominance may become worse when first beginning natural progesterone cream. When first introducing progesterone back into the body after an extended period of progesterone deficiency, the estrogen receptor sites ‘wake up’ (are stimulated), enhancing the action of estrogen for a short period of time. This is a sign that the body is responding well to the progesterone, even though at the beginning it can exacerbate estrogen dominance symptoms such as breast tenderness and swelling, spotting, fluid retention, dizziness, hot flashes, fatigue, headaches and nausea. This can be very worrisome, but should level out and go away over the next couple of cycles, as progesterone levels increase.

3. Stress affects progesterone levels. How? Stress increases cortisol levels. Cortisol competes for progesterone receptors; the higher the stress the more cortisol the body produces. This means that those receptor sites may be occupied by cortisol rather than progesterone, which may require temporary increase in progesterone supplementation. If you are not managing your stress levels, the natural progesterone cream you are currently using may not be effective because of elevated cortisol levels. Make stress reduction part of your plan to balance hormone levels.

4. Severe progesterone deficiency requires more time to increase progesterone levels with progesterone cream supplementation. It takes anywhere from 4-12 months to bring progesterone levels back up in women with very low progesterone levels. Following a loading dose protocol may help to bring the levels up quicker, but consistency of use over an extended period of time is best. For women who are trying to conceive, a realistic plan is going to help achieve pregnancy and prevent miscarriage due to progesterone deficiency. Give yourself many months of progesterone cream supplementation before even trying for a baby, to help prevent the likelihood of miscarriage.

5. Is it okay to use natural progesterone cream if you don’t know if you have low progesterone levels? It would be best to know if you have low progesterone levels or not. You would not want to work to increase progesterone levels if you don’t need to. Over time, using progesterone cream when it isn’t needed may create a situation in which too much progesterone is in the body. That being said, there are many clear signs of progesterone deficiency and testing is relatively easy. There are at-home saliva hormone tests and your doctor can test your levels as well.

6. A one-time overdose of progesterone cream is virtually impossible. That being said, it does not mean you should use more than the suggested dosage. It does mean that the female body can withstand high levels of progesterone in the body relatively well, because during the last trimester of pregnancy, the placenta is producing 300-400mg of progesterone a day. If you accidentally use too much or apply the cream more than 2 times in a day, you should be fine. Even if you used a whole bottle in a day, it may just make you feel very sleepy. Be sure you always stay within the recommended dosage guidelines recommended by your healthcare practitioner, or on the label of the product you are using.

7. Split dosage up between morning and nighttime application. Apply the cream once in the morning and once in the evening before bed. Using it before bedtime may help some people to sleep better. Splitting the dosage up ensures 8-12 hours of sustained delivery. If you apply it all at one time, only once a day, it will still only last 8-12 hours, leaving the other 12 hours where you are not receiving any. The split dosage ensures optimum progesterone levels are maintained.

8. Each cycle, stop using natural progesterone cream only when you have confirmed you are NOT pregnant. This means if you are trying to get pregnant while using NPC, be sure to continue it until you have definitely confirmed you are not pregnant. If you get a positive pregnancy test result, continue on with the progesterone cream. Be sure not to skip a day of use of NPC in pregnancy. Doing so may result in a sudden drop of progesterone levels, which may cause a miscarriage. Have two bottles on hand at all times to ensure you don’t run out.

9. Discontinue use of progesterone cream by weaning off of it over time. When you decide it is time to stop supplementing with natural progesterone cream, simply reduce the amount you use each time you apply it. Do this on the last cycle you plan on using it. If you are pregnant, do not do this until at least the 16th week of gestation, when the placenta takes over progesterone production.

10. There are certain health conditions in which natural progesterone cream supplementation should be avoided. If you have a history of gestational pemphigoid (dermatosis of pregnancy), jaundice of pregnancy, severe active liver disease, hepatitis, rotor syndrome, Dubin-Johnson syndrome, or unexplained/abnormal vaginal bleeding you should not use natural progesterone cream.

Want to know more? Be sure to read over our complete Progesterone Fertility Guide and our Progesterone & Fertility Q&A!

1. Rollins, Catherine P.(2007). 10 Things Every Woman Should Know About Natural Progesterone. A Making Plans Production.
2. Taber’s Cyclopedic Medical Dictionary. (1997). pp. 1431. Philadelphia: F.A. Davis Company.

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  1. Hello, I am confused with when to stop the progesterone cream and why it needs to be stopped during menstration. I use Nuvaring for birth control. My question is do I stop using the progesterone cream once my menstration is here or once I take out the Nuvaring for the week for my period to begin?

    Also I am afraid to stop using it because before I started using it I was a total raving mad woman, crying and angry and just pushing people away. I don’t want to be that women again for 7 days out of the month.

    • Dear Vicky,

      The goal in using natural progesterone cream is to mimic a natural menstrual cycle and help the body to establish its own cycle, including regular ovulation. Progesterone is typically not produced in large quantities by the body during menstruation. Using natural progesterone cream prior to ovulation is likely to stop ovulation.

      Does your doctor know you’re using progesterone cream with NuvaRing? Could it be the NuvaRing that is making you so emotional?

      We aren’t able to suggest progesterone cream use with hormonal medications without a doctors guidance. It may be best to ask him/her when it is best to use/stop. With that, progesterone cream used to support a healthy menstrual cycle is suggested only for the two weeks before menstruation starts not during a period or before ovulation.

  2. Dear Elizabeth, Am a 50 y. old male and was advised to apply progesterone cream (1%) for a few weeks. Is there a difference between p. cream for women and for men? What is the danger of developing ‘moobs’ should I apply the cream 6x p. week for 2 months?

    • Dear Diversey,

      This would be a better question asked of your doctor or pharmacist. I am honestly not certain of the dangers for progesterone cream use for men. It is probably going to be best to choose a pure natural progesterone cream that does not contain herbs. Emerita Pro-Gest is but one of I am certain many on the market.

      My best as you naturally support hormonal balance!

  3. Can i take progesterone cream and vitex at the same time?

  4. Hello. Can you tell me what test results should look like when testing for progesterone?

    • Hello Gin!

      The most appropriate time to measure serum progesterone is mid luteal phase (either 7 days after ovulation, or 7 days prior to expected menses). In general for women, most resources say that progesterone levels tested mid-cycle should fall in the range of 5 to 20 ng/mL or 15.90 to 63.60 nmol/L.

  5. I have read through the Progesterone Cream Uses and I think it will be useful to me. The problem is that I don’t know where I could it. Please help.

  6. I have started to use Progesterone (in cream) 3 weeks ago. I’m 52 (pre-menopause) . Now I have my period (for 4 month I hadn’t it) . Should I stop to use progesterone during my period (5 days) or continue? Thanks for your attention!

    • Dear Paola,

      Natural progesterone cream is best stopped during menstruation, yes. You may appreciate the book What Your Doctor May Not Tell You About Menopause (TM): The Breakthrough Book on Natural Hormone Balance.

  7. I wanted to know if it is safe to use a progesterone/estrogen facial cream while taking birth control pills, I’ve been using a progesterone/estrogen cream 3 days so far, I’m 29 and using birth control pills and I want to know if there is any risk of lowering the effectiveness of the pill while using the cream.

    Thanks in advance,

    • Dear Natalie,

      I am not a doctor or pharmacist, nor have I heard of progesterone/estrogen facial cream to be honest. Please reach out to your doctor or pharmacist (a simply phone call may do). If you are concerned about the effectiveness of birth control and having intercourse, perhaps an additional form of protection would help ease the worry.

  8. Hello,

    I had my progesterone was confirmed low at 79.18pg/ml via a saliva test. My question is what dosage of progesterone do I use? I have read anywhere from 20mg to 250mg. I started using it this past month and noticed 5 days out from when I was supposed to start my period that I had brown spotting and some cramping. I reduced down to 40mg and all the symptoms went away. My period came about 9 days late. Was what I was experiencing normal and should have continued at the 80mg?

    Thank you!

    • Dear Kristina,

      Your doctor is best able to tell you the correct dose of progesterone for your needs. Do call him or his nurse. The dose may differ if you are taking an oral progesterone supplement versus using a progesterone cream.

  9. So I’ve been using the Emerita cream twice daily for 2 cycles now after an early miscarriage. My first cycle used it from day 14 until my period appeared. This 2nd cycle I’m 3 days late, but have had 2 negative pregnancy tests. I do ovulate later than day 14, and had a short luteal phase prior to starting the cream. I’m worried I’ve just tested too early since I’m only 12 dpo. How do I know when to stop the cream?

    • Dear Lauren,

      Did you begin progesterone cream before ovulation this cycle? Was the luteal phase the first cycle you used progesterone cream normal, meaning that it was at least 12 days long? Some women to have to stop progesterone cream use for menstruation to begin. This can differ from cycle to cycle as well, as the body adjusts to it and anything else you are doing to support fertility health. If you actively tried to conceive, it may be best to wait to test again before stopping the cream, but it you started progesterone cream before ovulation, ovulation may have been suppressed.

      If you would like to share more with me in private, do contact me here…