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5 Ways to Benefit Your Fertility by Taking DIM

5 Ways to Benefit Your Fertility by Taking DIM

DIM is derived from cruciferous vegetables such as kale, broccoli, and cauliflower.

DIM is derived from cruciferous vegetables such as kale, broccoli, and cauliflower.

Diindolylmethane, or DIM, is a plant nutrient isolated from cruciferous vegetables that promotes the breakdown and synthesis of estrogen within the body. It helps the human body reduce its levels of “bad” exogenous estrogens in turn increasing “good” endogenous estrogen.

What is “Bad” Estrogen?
“Bad” estrogen comes primarily from exposure to xenohormones – man made and environmental chemicals that bind to estrogen receptor sites and act like estrogen within the body. They contribute to the formation of extra estrogen receptor sites and also prevent the liver from eliminating excess estrogen. Increased levels of “bad” estrogen are also promoted by obesity and contribute to hormonal imbalance.

Then, what is “Good” Estrogen?
Our body’s “good” estrogen has many responsibilities in terms of supporting healthy fertility. For women, estrogen helps the follicle in an ovary to mature in preparation for ovulation, supports a healthy menstrual cycle, and helps to create a thick endometrium in preparation for implantation. In men, estrogen helps to regulate the process by which sperm matures.

5 Ways DIM Benefits Estrogen Levels

1. Promotes healthy estrogen metabolism – DIM helps the body break down “bad” estrogen to be properly eliminated allowing for “good” estrogen to do its job and participate in healthy hormonal balance. “Both DIM and I3C [the plant nutrient isolate] induce the activity of phase I and phase II enzymes involved in the biotransformation and elimination of steroid hormones and carcinogens in vitro,” according to the Memorial Sloan Kettering Cancer Center.

2. Supports hormone balance – By helping the body eliminate excess estrogen, DIM becomes an ally to and a beneficial supplement for those dealing with estrogen-dominant fertility health conditions such as:

  • uterine fibroids/polyps
  • endometriosis
  • PCOS
  • ovarian cysts
  • irregular menstrual cycles
  • immature egg maturation
  • immature sperm maturation

3. Decreases the symptoms of estrogen dominance – DIM may aid in the relief of the following symptoms associated with estrogen dominance:

  • acne
  • PMS
  • hair loss related to hormonal imbalance
  • helps regulate an irregular menstrual cycle
  • supports cervical health
  • breast tenderness
  • pain associated with endometriosis
  • slow metabolism
  • weight gain

4. Helps to protect cellular health – “Both plant indoles [DIM] and “good” estrogen are known to be cell protectors through their action as antioxidants,” according to Doctor’s Michael Zeligs and A. Scott Connelly. Antioxidants help protect the body from free radicals that damage cellular health. “Good” estrogen is believed to help the body regulate proper cell growth, while naturally eliminating the damaged/dead cells, a process called “programmed cell death”. “Bad” estrogen is thought to promote the growth of abnormal cells.

5. Supports mood, libido and fat-burning metabolism – Compared to other hormones in the female body such as estrogen and progesterone, women have lower levels of testosterone. Despite the lower levels of testosterone, the right levels of testosterone in women is important. For women, testosterone plays a key role in mood, libido, and fat-burning metabolism. Excess “bad” estrogens can block hormone receptor sites which prevents other hormones from actively and efficiently doing their jobs. Because the female body already naturally has lower levels of testosterone, any drop in this could be detrimental to health. DIM helps rid the body of excess estrogen which, in turn, helps testosterone in the female body stay active. Active testosterone supports positive mood, sex drive, and active aerobic metabolism – the process whereby oxygen, blood glucose, glycogen, and fat is used to fuel the muscles of the body primarily during exercise. “Good” estrogens naturally regulate energy within the body; they are the controllers of metabolism.

Supplementing with DIM: What You Need to Know

DIM does not have estrogenic activity, does not mimic estrogen, and will not make up for estrogen deficiency. What it can do is help the body to improve hormone balance and protect cellular health. If you have been struggling to overcome a fertility issue associated with estrogen dominance or are looking to improve egg health, or hormone balance, consider supplementing with DIM as part of your natural fertility program.

While cruciferous vegetables contain DIM, there is no way to get enough of this nutrient through cruciferous vegetable intake alone. To reap the benefits DIM has to offer, it is best taken as a nutritional supplement. To learn more about DIM click here…


Dr. Christine Traxler M.D., OB/GYN
Dr. Christine Traxler M.D., OB/GYN

Dr. Traxler is a University-trained obstetrician/gynecologist, working with patients in Minnesota for over 20 years. She is a professional medical writer; having authored multiple books on pregnancy and childbirth; textbooks and coursework for medical students and other healthcare providers; and has written over 1000 articles on medical, health, and wellness topics.  Dr. Traxler attended the University of Minnesota College of Biological Sciences and University of Minnesota Medical School,  earning a degree in biochemistry with summa cum laude honors in 1981,  and receiving her Medical Doctorate degree (MD) in 1986.

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  1. Avatar

    Hi there. I’ve been taking DIM for about 11 months and it has helped me immensely – it has cured my hormonal acne, drastically reduced period pain and PMT, and made my menstrual cycle regular. I’m just wondering – if DIM has had these positive benefits, is there a chance that stopping taking it once pregnant, this could actually have an adverse effect on baby seeing as the DIM has helped get my body into a good, balanced hormonal state? What if the hormones get unbalanced and I miscarry? I’m just not sure what to do – it seems that taking something when it has helped immensely to regulate hormones could be a good idea, to maintain healthy hormone levels. What are your thoughts? 🙂

    • Dear Sarah,

      We can not suggest using DIM in pregnancy and if you wish to continue it at that time, it will be best to talk through this and work one on one with a herbalist, midwife or naturopath near you. They can help you know what is best for your health and the health of your pregnancy.

      That said, DIM does not contain hormones or have a direct impact on hormone production. It helps the liver properly metabolize excess estrogen. The goal really is the help the liver “remember” how to do it’s job properly and do it well, so that in time, DIM will no longer be needed. The goal being that a continued healthy diet and lifestyle will be what the body needs to continue to maintain balance. I have not ever heard of a pregnancy being adversely affected due to stopping DIM when pregnancy is confirmed.

      We can not suggest continuing Fertilica DIM Complete into pregnancy.

  2. Avatar

    Hi, I have been taking dim for 2 weeks at the dosage of 300mg, after this I started to have symptoms of headache, dizziness and having bad night sweats, was just wondering if this is normal or is this an adverse affect? Thanks.

    • Dear Vanessa,

      I’m sorry to hear this! I am not aware of DIM causing these side effects. Some women do experience these issues when hormones shift or are trying to rebalance. Did you begin taking anything else or using any other natural therapies?

      It may help to reduce the amount you are taking to see it the issues subside. I do hope so!

  3. Avatar

    Hi, I have just started taking a DIM supplement after being diagnosed with Endometriosis. I had laparoscopic surgery a few weeks ago where the Endo was discovered and removed. We are trying to conceive, so I was wondering whether DIM supplements are safe to take during pregnancy, or whether I should stop taking them when (hopefully) I find out I am pregnant.
    Thanks so much in advance.

  4. Avatar

    Can this be taken if you are on Thyroid medicine?

  5. Avatar

    This is so interesting! I never knew about DIM before. I have high estrogen/low progesterone and had a myomectomy in January. We are now TTC and I’ve been looking at taking Vitex to help level things out but am wondering if I should take DIM instead? Or both?

    • Dear Chelsea,

      Fertilica DIM Complete can be combined with Fertilica Vitex and many with elevated estrogen and hormonal imbalance do combine them. Ultimately it’s best to keep researching about DIM to help you decide if it’s right for you.