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Progesterone Fertility Q&A

Progesterone Fertility Q&A

Fertility Q&A: ProgesteroneTo learn more about using progesterone for fertility visit the Fertility Progesterone Guide.

1. Q: How should you use progesterone if you are trying to conceive?
The basic rule is to follow the instructions on the bottle. You want to mimic your natural cycle as much as possible.

For most uses you would begin to use progesterone by using this calculation:
Figure out the first day of your period (coming up next). Subtract two weeks. That day would be the first day you start using the progesterone cream.

The general suggested use for progesterone cream is 40mg of cream daily, applied in a split dose, 20mg in the morning and 20mg in the evening during the two weeks before your period as shared by progesterone expert Dr. John Lee in his book Dr. John Lee’s Hormone Balance Made Simple: The Essential How-to Guide to Symptoms, Dosage, Timing, and More. If actively trying to conceive, it is best to test for pregnancy before stopping progesterone cream a day or two before the expected period. Progesterone cream should be continued if pregnancy is confirmed while using it (with the guidance of your healthcare provider).

Example: An average cycle length is 28 – 30 days. In this case you would begin using progesterone around day 14 of your cycle, counting the first day of your period as day 1. If your cycle is shorter or longer than the given example, you would start two weeks before day one of when your period is due. If you have no period at all then you would choose a date and work from there.

2. Q: I have found out that my progesterone is low. What does this mean to my reproductive health?
When saliva hormonal tests show low progesterone levels, that could indicate that you have not ovulated or that you are not producing the proper amount of progesterone after ovulation – which is called luteal insufficiency. The correct amount of progesterone after ovulation is very important for maintaining a healthy pregnancy.

In a study published in the Lancet, a group of 18 regularly cycling women, average age 29, seven of them (39%) were found to not be ovulating and were not producing progesterone.

3. Q: If someone has PCOS and/or doesn’t have a regular menstrual cycle, how do they know what days to take the progesterone on?
In cases where your cycle is an 18- or 32-day cycle, starting on day 12 or 14 would not be good. To figure out when would be the best time for you to start and end your progesterone use get out a calendar…

Figure out what day 1 is of your cycle (this is when your next period is due). This is based on what your cycle is and what is normal for you. Then count backwards two weeks. That is when you start using the progesterone cream.

This works because despite the length of a cycle, the days between ovulation and day 1 of the period is consistently two weeks.

4. Q: Does progesterone cream benefit those of us with PCOS, without a regular cycle? Or are we better off just taking Vitex and/or Maca?
A: With PCOS, progesterone supplementation can help to make a big difference. It can seem confusing when you should use it since usage is based on a menstrual cycle. In this case, choosing your own cycle can help to establish a pattern. Mimicking a general cycle is best. Following the same suggested usage as someone who has a cycle, just choose your own and mark it on the calendar.

Vitex works great in conjunction with progesterone cream. Vitex is working on the underlying imbalance (which takes some time) while the progesterone helps in the current cycles.

5. Q: If I have an irregular cycle and don’t menstruate sometimes, how should I use progesterone cream?

A: Figure out what day 1 is of your cycle (this is when your next period is due). This is based on what your cycle is and what is normal for you. Then count backwards two weeks. That is when you start using the progesterone cream.

If you do not menstruate at all then you may want to check out our article on bringing your period back and talk with your health care provider to find out what the imbalance may be.

6. Q: I know that I am ovulating. Do I still need progesterone? Could my progesterone levels still be low?
Depending on what your fertility issues have been in the past. Many women ovulate and then have a drop in progesterone levels after ovulation (the luteal phase). This may be the cause of recurrent miscarriages or the inability to get pregnant. One way to tell if this is happening is to start fertility charting.

Fertility charting or Basal Body Temperature charting can help to determine the availability of progesterone in the luteal phase. There will be a slight rise in temperature after ovulation has occurred and progesterone has increased and stay increased until the period is about to begin. It will then drop. If you are pregnant, the temperature will stay at its increased amount.

7. Q: Is it possible to conceive if I have low progesterone levels?

A: It is possible to conceive with low progesterone, but it may be more difficult. It may be hard to maintain a pregnancy if you have low progesterone. Please read the answer to the question before this one.

8. Q: How do I know if I have low progesterone?
There are a couple of different ways to find out if you have low progesterone.
Hormones testing can be administered by a doctor, naturopath or through labs online. There are a couple of test options. Tests range from charting your menstrual and basal body temperature, finding out the length of your luteal phase, or taking saliva tests to find out your progesterone levels. The progesterone questionnaire on this page can help to point out signs of progesterone deficiency while these tests help to confirm it.

Naturopathic Doctor Lara Briden shares common signs of progesterone deficiency are: “short luteal phase, the time between ovulation and your period. It should be at least 11 days; low temperatures in the luteal phase; fertile mucus in the luteal phase; pPremenstrual spotting.”

BBT Charting
Basil Body Temperature charting can help to determine the availability of progesterone in the luteal phase. There will be a slight rise in temperature after ovulation has occurred and progesterone has increased.

Length of luteal phase
If the date of ovulation is fewer than 11 days before your period, this could suggest luteal phase defects. You can detect ovulation using BBT charting and/or by using ovulation detector strip tests.

Saliva Hormone Testing
Dr. John Lee was very adamant that testing for hormones and progesterone should be done through saliva testing, not blood testing (almost all doctors will test the blood). This is because a blood test may not show an accurate picture of available hormones. Most of the time the hormones in your body are not usable. They are tightly bound to proteins in the blood stream. Only 1-2% are bio available at a time to enter the tissues of the body. Blood tests measure only the total level of hormones in the bloodstream. Dr. Lee suggests saliva testing is more accurate because of the salivary gland being the one of the tissues that bioavailable hormones enter.

You can order an “at home” saliva test that you will take at a certain time during your cycle and then send away to a lab for analysis. They will then mail back the results so you can find out if you have any hormonal imbalances.

9. Q: Can I have both low progesterone and low estrogen?
Yes. This sometimes shows up as a luteal phase defect.

10. Q: What is the difference between natural progesterone cream and progesterone that is prescribed by a doctor?
Natural progesterone cream contains “bioidentical hormones”. These are hormones that are identical to the ones in your body. Most of the progesterone prescribed by doctors has been molecularly altered to create a kind of “pseudo-hormone” or a synthetic hormone. This is done so the drug is patent protected. Natural progesterone cannot be patented as it is natural. Since the structure of the progesterone has been altered in prescribed progesterone, it will not act the same in the body as natural progesterone and may cause dangerous side effects.

11. Q: Can I use wild yam cream instead of progesterone cream?
Wild yam cream is not the same as progesterone cream. There is a substance called diosgenin in soybeans and wild yams that is extracted and then modified in a laboratory to create the progesterone found in progesterone creams. Your body is not able to turn diosgenin directly (from wild yam cream) into hormones itself.

12. Q: What is the difference between Fertilica Progesterone and Emerita Progesterone?
We sell two different kinds of Progesterone Cream, the Fertilica (our brand) contains other herbs which we find important for hormonal balance and Emerita which is just plain progesterone cream. The Emerita is mostly for women who wish to use progesterone cream during pregnancy.

The progesterone in both products are formulated from a substance found in Mexican wild yams. United States Pharmacopoeia (USP) denotes a recognized standard of purity and strength. It is sometimes referred to as “human-identical” or “bio-identical” progesterone, which differentiates it from synthetic progestins. USP classifies the progesterone as the highest quality available. Both progesterone creams contain USP grade natural progesterone.

Fertilica Natural Progesterone cream contains 20mg of USP Progesterone per full pump. The bottle contains approximately 70 pumps of hormone balancing herbs. This product is mostly used by our customers while trying to conceive as it contains other beneficial hormone balancing herbs.

Emerita: Each 1/4 tsp contains approximately 20 mg of USP Progesterone. Mostly used by our customers during pregnancy since it is herb free.

13. Q: Which is the best to take if I have low progesterone… progesterone cream, maca or vitex?
It depends on what is happening in your body. Here are some general guidelines to how each works:

Progesterone cream is a direct way to increase progesterone levels. This is helpful in the case of luteal phase defect, preventing recurrent miscarriages and reversing conditions such as endometriosis and ovarian cysts.

Maca is a nourishing food for the endocrine system, aiding both the pituitary, adrenal, and thyroid glands (all involved in hormonal balance.) Maca has the ability to affect key hormones in both women and men without containing hormones itself. In women, maca has been shown in studies to help regulate estrogen and increase progesterone (if that is what the body needs). In men, it has been shown to regulate estrogen and increase libido and sperm health.

Vitex has been found to help normalize ovulation, improve a short luteal phase and reduce Polycystic Ovary Syndrome (PCOS), all known fertility inhibitors. In one study, vitex helped normalize progesterone levels and increased the luteal phase from 5.4 days to 11.4 days. In addition, two double-blind studies show vitex extract increases a woman’s fertility and chances of successful conception.

14. Q: Can you use both progesterone cream and vitex or maca?
Yes, progesterone starts to have an effect the cycle that you start taking it. Vitex and maca both take time to have their effect. The previous question explains in detail the difference of the three. It is also not necessary to take all three. Every situation is unique and different.

15. Q: If I am using Maca to boost my progesterone should I stop taking it once I become pregnant?
Maca has been used for thousands of years by the peoples of Peru, and they eat it daily, even during pregnancy. Acute toxicity and cytotoxicity studies have shown no potential toxicity for Maca. Hundreds of thousands of people have used maca with no reported side effects. That does not mean that maca should be continued into pregnancy though. There are currently no studies to prove that maca is safe for pregnancy, so it may be best to avoid taking it if you are pregnant. If you are already taking maca and are pregnant or plan on becoming pregnant, you can learn how to safely discontinue taking maca in early pregnancy by clicking here…

16. Q: I am using Vitex to increase my progesterone levels should I stop taking it once I become pregnant? Is it safe to take during pregnancy?
Botanical Medicine for Women’s Health by Aviva Romm, MD states that vitex may be used safely in pregnancy up to the second trimester to help prevent miscarriage due to low progesterone levels. A placebo-controlled study was performed on pregnant rats, to see if taking vitex in pregnancy had a teratogenic or mutagenic effect on offspring. Results showed that even with vitex levels administered 74 times the dosage typically consumed by humans, no toxicity nor aberrations in fetal development of the rat offspring were seen. The Botanical Safety Handbook provides no contraindications to use vitex during pregnancy. To learn when and how to safely wean off of vitex in pregnancy, please click here…

While Vitex can be used to help a miscarriage that is acute, it is best to use at least 3 months prior to conception for pregnancy preparation. Once pregnancy is confirmed, it would be best to contact a natural health care practitioner to help determine where progesterone levels are at. If your doctor feels that you need extra progesterone support, they can help you transition from vitex use to natural progesterone cream use, which is a more reliable way to maintain stable progesterone levels.

17. Q: I have been taking progesterone and am now pregnant. How much progesterone should I use for pregnancy and how long should I use it for?
While pregnant, it is best to work with your health care provider to help monitor and guide your progesterone usage. When you do become pregnant and you have been using progesterone, you want to make sure you do not stop taking it. A drop in progesterone levels can cause a spontaneous abortion (miscarriage) to occur.

In the first trimester of pregnancy, progesterone production is the sole responsibility of the ovaries, which can fail to produce sufficient levels to maintain the pregnancy. By the second trimester, the placenta itself is responsible for producing progesterone, and it hikes the level of this hormone to 486% higher than the non-pregnant norm.

If you are taking progesterone and get pregnant, you must continue taking progesterone until at least the 16th week. I personally would not stop if I had seriously low levels to begin with. But it is best to work with your health care practitioner if this is the case. They will continuously monitor your levels to make sure they are healthy for pregnancy.

18. Q: Is progesterone cream safe to take while on the Fertility Cleanse?
If you have been taking progesterone cream before starting the Fertility Cleanse, then continue to use the cream as you have been.

If you are starting the Fertility Cleanse and progesterone cream at the same time, I would suggest that you wait and begin the cream after your cleanse. The reason for this is that the Fertility Cleanse has a lot of different herbs that are going to be working on the endocrine system. It will be hard to monitor yourself and see how the progesterone is affecting you. Starting the progesterone cream the cycle after you have completed the Fertility Cleanse makes it easier to see how you are doing with the progesterone.

19. Q: Does it matter whether natural progesterone cream is made out of soy or wild yam?
No. There is a substance called diosgenin in soybeans and wild yams that is extracted and then modified in a laboratory to create the progesterone found in progesterone creams. Your body is not able to turn diosgenin directly into hormones itself. So taking just a soy supplement or using wild yam cream will not have the effects that progesterone cream does. It can be confusing because of soy’s phytoestrogen ability to have estrogen-like effects. But those come from a different part of the plant, which is accepted by your body.

20. Q: What is the difference between progesterone and progestins?
Progestins are a synthetic form of progesterone. While progesterone found in progesterone creams is natural and identical to the progesterone in your body, natural progesterone is much safer to use than progestins, which can have serious side effects. During the third trimester of the pregnancy the placenta naturally produces 300-400mg of progesterone daily. If progestins were given to the mother in that same dosage, serious birth defects could occur.

21. Q: Are there any side effects from using progesterone cream?
It is rare but, yes, there can be. Large doses (100mg) of progesterone can cause side effects, sleepiness, loss of libido, mild depression, exacerbated symptoms of estrogen deficiency, and serious hormonal imbalances.

If you take progesterone out of phase, then it may cause the timing of your period to change or spotting to occur.

The best way to avoid these side effects is to make sure to use the progesterone cream as directed, at the correct time of your cycle and not to exceed the recommend amount (10-30mg per application) or to work with a health care practitioner so your progesterone levels can be monitored.

22. Q: Can too much progesterone cause a light period?
It is hard to say, as there are many factors that can affect your cycle. The timing of when you use progesterone is very important. Taking it the wrong time can cause the cycle to be different. The best way to make sure you are using the cream at the right time is to calculate your progesterone start date by counting two weeks backwards from when your period is due.

23. Q: I have been using progesterone and am now spotting between periods. This never happened before? What is happening? Is it the progesterone?
A: Spotting could be from a variety of reasons… The most common is a too high dose of progesterone.

The second common is that your timing may be off. If your cycle has been 24 days for years and changes to a 28-day cycle after you’ve began using progesterone cream this could be a sign of changes happening or a confused body. The best way to make sure you are using the cream at the right time is to calculate your progesterone start date by counting two weeks backwards from when your period is due.

The third common reason for spotting is that when the body is making hormonal shifts it sometimes gets out of wack for a cycle or two as it is shifting to its new cycle.

24. Q: Can I use progesterone cream if I am on birth control pills?

A: We do not know for sure, but it would be best to not mix hormones or use herbal products that can have an impact on your hormones while on birth control. An educated guess is that the birth control would block the progesterone from the receptor sites, but we do not know.

25. Q: I am preparing for an IVF and will be taking medications. Can I use progesterone cream?
We would not recommend it. When you are preparing for IVF you will be prescribed a very specific hormonal protocol. It would be very dangerous to use anything with hormonal effects during that time. Speak with your doctor if you feel you have low progesterone levels.

26. Q: I am breastfeeding, can I use progesterone cream? What is the recommended usage?
A: Progesterone cream is not generally recommended postpartum or while breastfeeding. It has been shown to be helpful for the baby blues/postpartum depression though. Talk to your doctor about this, especially if you are breastfeeding as some evidence shows that progesterone can prevent lactation from occurring.

27. Q: Can using progesterone cream prevent menopause from happening?

To learn more about using progesterone for fertility visit the Fertility Progesterone Guide.:

Click here to purchase Fertilica™ Natural Progesterone Cream:

Have a question? Contact us or leave a comment down below and one of our herbalists will respond as soon as possible.


  • Lee, J. R., & Hopkins, V. (2006). Dr. John Lees hormone balance made simple: the essential how-to guide to symptoms, dosage, timing, and more. New York: Grand Central Life & Style.
  • Lee, J. R., Hanley, J., & Hopkins, V. (2005). What your doctor may not tell you about premenopause: balance your hormones and your life from thirty to fifty. New York: Grand Central Pub.
  • Hobbs, C. (2003). Vitex: the women’s herb. Summertown, TN: Healthy Living Publications.
  • Trickey, R. (2011). Women, hormones & the menstrual cycle. Fairfield, Vic.: Melbourne Holistic Health Group.
  • Weed, S. S. (1986). Wise woman herbal for the childbearing year. Woodstock, NY: Ash Tree Publishing.
  • Briden, L. (November 4, 2016). 7 Superpowers of Progesterone. Retrieved from
  • California PSR and CALPIRG. “Generations at Risk” Chemicals and Reproductive Health.PDF Retrieved from:
  • Romm, A. J. (2009). Botanical medicine for women’s health. St. Louis, MO: Elsevier.
Dr. Christine Traxler M.D., OB/GYN
Dr. Christine Traxler M.D., OB/GYN

Dr. Traxler is a University-trained obstetrician/gynecologist, working with patients in Minnesota for over 20 years. She is a professional medical writer; having authored multiple books on pregnancy and childbirth; textbooks and coursework for medical students and other healthcare providers; and has written over 1000 articles on medical, health, and wellness topics.  Dr. Traxler attended the University of Minnesota College of Biological Sciences and University of Minnesota Medical School,  earning a degree in biochemistry with summa cum laude honors in 1981,  and receiving her Medical Doctorate degree (MD) in 1986.

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  1. Avatar

    My husband and I have been ttc for over a year, and this month we used iui. The doctor told me to start taking progesterone suppositories the same day as the iui. I am taking 3 daily. I have read online that you should not start progesterone until a few days after ovulation, and since I had 6 follicles, I am not sure if ovulation has finished or not. I don’t want to risk a possible pregnancy by taking progesterone too soon, but I love my doctor and I know she is experienced. I just wanted some more input, if possible. Thank you!

    • Dear Bethany,

      It is going to be best to follow your doctors advice. She knows your needs best!

      There are so much information on the itnernet, not all valid, and none that specifically speaks to know your individual needs. There are also different schools of thought regarding progesterone use during the cycle. The guidance that we follow of Dr. John Lee suggests starting natural progesterone cream use the two weeks prior to menstruation, or cycle day 1.

      Take care!

  2. Avatar

    I have a 4 year old, but after I had him I was diagnosed with PCOS. My Husband and I have been trying for almost 2 years and I got told about Vitex from a friend of mine. Any pointers on how to get pregnant? My periods just come and go up to 50 days apart.

    • Elizabeth Willett, MA, CH

      Dear Sheena,

      The goal of our programs is to support the body in re-learning balance and/or supporting balance when fertility issues are present. The great part about herbs, supplements and natural therapies is that they often work wonders in doing this given commitment to dietary and lifestyle change is made as well.
      Consider supporting your body in re-learning balance by promoting healthy hormonal balance, a healthy uterine lining, regular ovulation, improved estrogen metabolism, reduced cravings for sweets and improved digestion. You can learn more and how to do the above in the following article:
      How to Reduce the Damaging Effects of PCOS on Fertility Through Diet and Herbs.

      I hope this is helpful!

  3. Avatar

    Hi Hethir,
    I am using the Emerita progesterone cream, and this is my second month, and my period is late. I had an ovulation test positive on day 11 and I started the cream on day 15th to ensure that I passed the ovulation phase. on day 29th I had a negative pregnancy test, and now I am on day 33 and no period yet. can you please give some feed back. I am also, using vitex and macca
    Thank you,

    • Hi Grace,

      When a woman experiences this type of issue, my first question is always, “Do you have low progesterone levels confirmed through testing?”

      Second, it may be that your body is going experience a slight “cycle shift” since you have begun 3 new supplements that have an action on hormones. This is pretty normal when women first begin these 3 supplements, whether they are begun all at the same time, or separately. This typically regulates over the next cycle or two.

      If you don’t know if you have low progesterone levels or not, supplementing with progesterone cream may not be your best option.

      I hope this helps you to think about what may be going on. I have another article you might like reading – Natural Progesterone Cream Use: 10 Things You Should Know

      All the best!

  4. Avatar

    I take high doses of progesterone (in liquid drops and also cream) for migraines. Can this prevent ovulation or prevent me from getting pregnant?

    • Hi Kari,

      If you are taking it all month long, then yes, there is the potential to suppress ovulation, which would prevent pregnancy. I am hoping a healthcare practitioner prescribed this for you, at the right dose for your needs. If you are wanting to get pregnant or have questions about how you are using progesterone, it would be best to talk to your healthcare practitioner about this.

  5. Avatar

    The instructions above state to start progesterone 14 days before start of next cycle then stopping a day or two before next period.

    If I were to conceive in my cycle just before starting pg cream, and then stopped before I thought my next period began…I would think without knowing yet I was pregnant…my question is, would that stopping of pg cream bring on a miscarriage potentially? Because as I understand it, it would be too early to know at that stage if I was pregnant. Bit confusedonthis part. Thanks.

    • Hi Marie,

      You are correct. Do not stop applying the progesterone cream when trying to conceive and not sure if you may be pregnant or not. Discontinue application only if you have confirmed that you are not pregnant through testing. If you think you may be pregnant, continue on. If you get a positive pregnancy test, continue applying a pure progesterone cream (that contains no herbs) and contact your doctor. Suddenly discontinuing application of progesterone cream anytime between the beginning and 16th week of gestation, may potentially cause a sudden drop in progesterone, which may lead to miscarriage. Learn important tips about natural progesterone cream use here:

  6. Update 2014 – We are back! We have been away for a while and we sure have missed all of your wonderful questions and thoughts on our articles. I apologize for past comments that we were unable to get to. Moving forward, one of our staff herbalists will be here to respond to comments! We look forward to connecting with our readers once again!

  7. Avatar

    Hi. I am bout in the same situation as Kim was
    And wondered what she ended up doing?
    I had a mc in mar, so when I got pg this last
    time( 5wk2d) I went to the dr right away
    I got a blood test n a 10 day progesterone pills
    prescription, they said to take it till they
    find out if my levels are good, they called today
    n said they’re good n I can finish my 5 pills
    n then I don’t need more. I heard it’s bad to quit
    And I wasn’t sure what to do, I am wary of
    just stopping but my dr should kno wat he’s talking
    about. But I don’t want to go through another mc!!!!
    My last pg I was using natural wild yam
    Progesterone cream. Thanks.

  8. Avatar


    So if Vitex is safe to take along with the progesterone cream, how do you recommend us to take it? Should we take Vitex on Day 1 of our cycle up to Day 11, stop, then on Day 12 to 26 we start applying the progesterone cream? What would be the best solution for this?

    Thank you!

  9. Avatar

    Hi Darlene,

    I started using a natural progesterone cream yesterday and it was day 12 of my cycle. I am trying to conceive but I don’t think I ovulated yet and I am concerned that I will not ovulate now as a result of using the cream. Is there a chance I could still ovulate? Also, the cream I bought contains phytoestrogens, is that going to cause problems with conceiving too?

  10. Avatar

    Hi, I’m 49 yrs old and my ob/gyn put me on progesterone because I was getting having bloody discharges in between periods. He did all the tests and biopsy and found nothing but a thicking in the lining of my uterus. I have been on Progesterone for 4 months taking it on the 16th day after my period. The 1st month I had passed quite a few blood clots during my period which was heavier then usual. Each month seem to get a little better until last month when it felt like I wet my pants. It was a discharge with light colored blood lasting a couple days. This month I started taking it again and after 3 days I got my period (10 days early which is not normal for me.). Should I continue taking it or get off of them?


  11. Avatar

    i need advice i starting taking a fingertip worth of natural radiance progesterone cream since cycle day 12 and im currently on cycle day 21 and have yet too ovulate and wanted to know did the progesterone cream suppress my ovulation??? and if i stop it now would i be able to ovulate or have to wait a whole new cycle??? because im trying to conceive and would love to get a positive for fathers day???

  12. Avatar

    I ve been married fo 14yrs now no child and I ve had 3misscarriages due to low progestrone And has been tryin to concive to no avail pls what will I do to have a child of my own Thanks

  13. Avatar


    I have been ttc for 6 months and had an early miscarriage 2 months ago. I have been dating my cycle and ovulation and have a luteal phase of about 10 days, which I understand is low. I have just found out I am four weeks pregnant and am worried that I may have an early miscarriage again. Would using progesterone cream help me now?

    Any advice would be much appreciated,

    Thanks, Rebecca

  14. Avatar

    I have PCOS and used progesterone cream to get pregnant with my first child. Now almost 5 yrs later, we are trying to get pregnant again. My cycles are much more regular now but still having trouble conceiving. I have used progesterone cream for 2 cycles now. My cycles were around 32 days and I would ovulate around day 18. After using the cream, I still ovulate on day 18 but my cycles have been 29 and 27 days long. I have used the cream twice a day and am wondering if I have taken too much. Would you recommend me continue using it twice a day or back down to once a day? I am using the Arbonne prolief cream. I would appreciate any suggestions. Thank you!

  15. Avatar

    My infertility specialist just prescribed me 200 mg progesterone to use vaginally at bed time. I have factorV and will be taking lovenox once I get another positive home pregnancy test. I was wondering if taking a B6 vitamin at the same time as the progesterone will be ok?

  16. Avatar

    Hey I recently seen my doc because my husband and I have been trying to conieve and nothing is working. I then got the news I have low progesterone normal estregone and am being referred to a specialist. Would the cream help me? Normal periods 29cd but not ovulating I don’t think. Thanks!!

  17. Avatar

    I was on 150mg of clomid then the dr. proscribed 3 weeks worth of 20mg progesterone pill sup. I’m now pregnant and I only have 6 days left of sup. I keep reading to continue the progesterone but should I be continuing the pills or get the natural creme?

  18. Avatar

    I have been using the yam cream which was recommend by an Acupuncturist (we’ve been TTC for 2 years now) and didn’t realize that I should stop applying it a couple of days before my period starts. Could not stopping it cause my period to not come? I have a 28 day cycle – it is now day 35 and I took a pregnancy test which was negative. I have very sore breasts – I stopped applying the yam cream.

  19. Avatar

    I have pcos…I’m take metformin 500(3*)a day, vitex 400mg (3*), prenatal vitamins and progesterone cream 480 pet oz. My fsh is 62.1, my Lh is 25, testosterone is 45, I am 5’3 187lbs, these were taken last year before I started these meds. I do desire to get pregnant do you know if this will help and can you give me any tips? FYI I don’t have a cycle unless on low dose bc I’m trying to bring it naturally.

  20. Avatar


    I have recently been diagnosed with PCOS and have started taking an all-natural, bio-identical Progesterone pill (my Doctor said that the cream would not be sufficiently “intense” with my situation) from a compound pharmacy. I am wondering what else I should be doing to try and help regulate my hormones. My husband and I are planning on trying to become pregnant once I have straightened out some of these health issues. Any advice would be greatly appreciated. Thanks!


  21. Avatar

    Hello! I’m 27, been trying to conceive for over 6 years now! I have PCOS although I don’t have facial hair and I’m not overweight at all. I’m 168m, 53 kg. I get my period every two weeks which made me think that I might have short luteal phase defect! I can feel that I ovulate some months but never been pregnant! I’ve done 2 ivf, one was a fresh cycle and the other was frozen. Both failed! Although my eggs were first grade and my uteruine lining was around 11 (thick enough as the doctor said) I’m so scared and helpless! Is there a possibilyy for me getting pregnant with PCOS and short luteal phase defect? Is my problem that complicated?
    Ps. The short luteal defect hasn’t been confirmed! I didn’t discuss it with my doctor yet but I’m guessing since I do get my period every 14 days! I can feel that I ovulate at times cause I get cramps and my ovaries feel weird “kicking feeling” but I never never been preg! I had my progesterone level tested once when I was taking clomid and the result was below avarage! It was 0. Somthing. Plz tell me what to do? Be frank! I’m tired of ppl giving me false hopes

    • Avatar

      i kinda havE the same problem. i take 400mg of progesterone every day and am 27 and trying to concieve…it is totally normal for people with progesterone disorders to have extremely irregular bleeding. I work at an OB/GYN clinic. once you do become pregnant they usually start you off besides something oral. sometimes if you are low on progesterone the wall of your uterus just sluffs off bc it has nothing connected, hence the early periods. hope that helped

  22. Avatar

    I didn’t realize that I should stop applying the yam cream a couple of days before my expected period (I have a 28 day cycle). Now it is 4 days since I was supposed to get it and I haven’t yet (i am worried I messed up my cycle because I kept using the cream) I took a preg test and it is negative. Should I wait until day 35 to take another test? I have had cramping prominently on my right side for about 2 weeks now with some light cramping throughout to my left and sore breasts. Should I stop applying the cream or continue?

  23. Avatar


    I took progesterone and I am pregnant . Should I continuing taking the same ?
    Please let me know . Now I am 4 weeks pregnant,, one doctor asks me to take the other no. Am confused 🙁
    I want a safe pregnancy .

    Thanks ,,

    • Hi Indira,

      If you are taking progesterone and get pregnant, you must continue taking progesterone until at least the 16th week. I personally would not stop if I had seriously low levels to begin with. But it is best to work with your health care practitioner if this is the case. They will continuously monitor your levels to make sure they are healthy for pregnancy. You can watch a video with Hethir, she explains what to do in better detail, watch it here:

      If you have two different doctors saying two different things about your progesterone levels, you need to be retested.

      Best Wishes,


  24. Avatar

    where can i get fertilica natural progesterone cream in uk

  25. Avatar

    I’ve been ttc for over a year now. I finally went to my doctor and she put me on Clomid and told me to take it on the 5th day of my menstrual cycle. Well my problem is that I still haven’t started my menstrual cycle and I was wondering if the progesterone cream would help me start my cycle, so that I would be able to start the Clomid. Before I went to my doctor my cycles were very irregular which is why I figured I wasn’t ovulating at all. So my question is, Will the progesterone cream help me start my period?

    • Hi Ashley V.,

      It would be best to first determine if you have low progesterone before beginning natural progesterone cream. You may want to speak with your doctor about why you have irregular menstrual cycles, rather than prescribing Clomid as a one time solution. Clomid may stimulate ovulation, but it does not solve the root of the issue at hand. What is causing you to be irregular?! Figure that out and you will have a lot more information to help you know where to begin.

      Best Wishes,


  26. Avatar

    I am low in progesterone and have an irregular period, therefore, don’t ovulate normally and my period comes when ever it wants. Can I use progesterone cream at anytime? because I know you are suppose to use it at a certain time but in my case, how would I use it?

    • Hi Patricia Pineiro,

      If you have not read our Progesterone Fertility Guide I highly recommend that as the best place to begin. There are different ways to use natural progesterone cream. For women who have not had a regular cycle for a long time and have confirmed low progesterone, you will want to learn about the inducing ovulation and the loading dose. These two methods are explained in the Progesterone Fertility Guide.

      Best Wishes,


  27. Avatar

    is there an increase in ectopic pregnency when progestiron is used for infertility? if so what is the cause?

    • Hi Hema,

      Fertility medications including chlomiphene citrate, pergonal and progestin (common in hormonal birth control) put a woman at risk for ectopic pregnancy, by altering the ability of the fallopian tube to contract and move the fertilized egg properly to the uterus.

      Best Wishes,


  28. Avatar

    Hi – I am 32 y/o and Ihave a 5 y/o son. I am trying to get pregnant with my second but have had no luck (4 months). I am currently on a regiment of natural progesterone 2x a day, everyday. I have been on this same regiment for about 2.5 years now for estrogen dominance. I have had amazing results and feel like a new woman..but I am wondering if I need to alter my schedule now that I am trying to conceive. My day 1 would be today 2/26/12 and I am a 29day cycle. Can progesterone cream prevent pregnancy from happening? I have read that if you are trying to get pregnant you may need to use the progesterone only after you have ovulated. Any thoughts?

    Thank you,


    • Hi Jennifer,
      Yes, progesterone cream can cause ovulation to NOT occur if used before ovulation. People actually use it on purpose to suppress ovulation in some cases. This could be a reason you have not had success thus far, but 4 months is not that long to be trying as well. To use progesterone cream properly for trying to conceive you would being the cream after you have ovulated. You can find out if you have ovulated by charting or using something like the ClearBlue Easy Monitor. If you use it before you will suppress ovulation.

  29. Avatar

    Hello. I am trying to conceive.The last four months I ovulate between cd12 and cd14 (confirmation by US) but my day 21 progesterone is very low (2-3ng/ml). If I use npc will my body ever produce normal progesterone levels whithout the hexogeneous help? Because of the very low progesterone levels do I need to do the suppression cycles?

    • Hi Magda,

      You may not need to do the suppression cycles, but learning how to do a loading dose for the first few months may be a good idea. Some women find that increasing the loading dose to up to 100mg a day is helpful in the case where very low progesterone levels are present. There is now way for me to know if your body will produce progesterone on its own or not. The overall goal should be to support the body through diet changes, exercise and herbs/supplements so that it can function on its own eventually, once good lifestyle and eating habits are in place.

      Best Wishes,


  30. Avatar

    I just got done with 5 pills of progesterone to kick start my period, since I have not had one in 3 months. When should I expect my cycle to start? I know my doctor told me, but I cannot remember how long she said it would be after I took the progesterone. Any help is apprecitated.

    • Hello Carolynn,

      Your doctor gave you prescription progesterone, we are not medical doctors and are not qualified to give information about medications. Please ask your doctor any questions you may have about prescription medications.

      Thank you,


  31. Avatar

    Hi there!

    My last cycle I went almost 3 months without a period. I have been taking Vitex and later added Maca root to it as well. I know these are slow acting and after much research about NPC, I went out and bought some. I used 40 mg a day–one pump in the morning and one pump in the evening. This brought on my period in 12 days. At that point I stopped using all herbs and creams to let my body cleanse.

    I am currently on CD 15 and have been charting my bbt. My chart looks great which is a surprise for someone who has been irregular for a long time. All my temps have stayed pretty close together, until yesterday at Cd 14 it dropped .4 degrees. I am assuming this is my pre-ovulation dip. Today on CD 15 my temp spiked almost .2 degrees above my coverline. I know you don’t confirm ovulation until 3 days of elevated temps.

    My question is: Do I start the natural progesterone now, or should I wait until I have naturally confirmed ovulation after 3 days of elevated temps and then start the cream? I just don’t want false temp readings by starting the cream today because I really want to know if I actually ovulated or not. At the same time, I am trying to conceive and I don’t want to hinder my chances by waiting on using the cream.

    Thank you in advance!

    • Hi Heather,

      It would be best to begin the progesterone cream after confirmation of ovulation, so there is not chance of suppressing ovulation, which may happen if natural progesterone is used too soon.

      All the best,


  32. Avatar

    Thanks Dalene!
    Thanks very much for the link to the cycle charting website. I am wondering whether I could be ovulating if I have not yet had a period? If I am not ovulating again yet would you know whether I should continue to take the progesterone cream every day until I know that I am?
    My doctor doesn’t seem to be too familiar as to what to do now that I am in the transition phase after having a baby and not yet getting a period,
    Very grateful for any further suggestions,

    • Hi Elaine,

      You would only use the natural progesterone cream in cycles, not everyday. If you use it everyday, it will suppress ovulation. The best way may be to mimic a natural cycle. So resting phase (mock period) day 1-5. Then on day 12-13 of the cycle the NPC would be started and continued until day 26. This may be done each month to help mimic and create a natural cycle. Learn ways to supplement NPC here:

      Best Wishes,


  33. Avatar

    Hi, I am trying to conceive and have two children. I came off the pill (microgynon) in August and have had 4 cycles since, the last 3 i know were 22,23 and 23 days long. I have charted temps this last month and belive i am ovulating around day 17. This would suggest a short LP. I have been taking 50mg a day B-complex, this made no difference. Would you suggest my short cycles are due to low progesterone? If so, would you reccomend i begin taking progesterone cream and if i did become pregnant, would i have to continue on this for the first trimester?

    Also, i sometimes experience light, darker spotting around day 10-11 is this normal?

    Any help/advice is appreciated!


    • Hi carolyn,

      It sounds like you may have Luteal Phase Defect (LPD). Low progesterone levels are the number 1 reason why LPD happens. Progesterone cream supplementation may help, but it would be best to know for sure if you are progesterone deficient first. There are at-home testing kits available. If you decide to supplement with natural progesterone cream, it is best to continue into pregnancy to help sustain progesterone levels and to help prevent miscarriage.

      Best Wishes,


  34. Avatar


    I am taking 50mg of progesterone that I started on day 15 of my cycle and took a pregnancy test on the first day of my missed menses but it showed negative. Is it possible to have a negative result using progesterone? I am still 2 days late. Any info would be much appreciated! Thanks!

    • Hi Tiffany,

      A regular suggested dosage of natural progesterone cream (NPC) is 20mg a day. It sounds like you are using a loading dose. Do you know if you need to take that much NPC or if you need it at all? It is not abnormal for a woman’s first menstrual cycle, after beginning the NPC to be absent or not come until later. Did you stop the NPC? That may help to bring on a period, but be sure you are NOT pregnant before doing that. It may be that you are using too much NPC? There is no way I can be sure, I just don’t have enough information.

      All the best,


  35. Avatar

    I started using NPC without knowing if I had low progesterone or not. I have PCOS and was told it could help with implantation. I am now 4 weeks pregnant, and my doctor has asked me to stop using the NPC. He did a blood test today and my progesterone level was a 24 which he was happy with. My question is, how do I know if the 24 was MY bodies level, or due to the NPC usage? If I stop abruptly now, will I be causing harm? I’m not sure what to do and fear stopping it cold turkey because the doctor may or may not understand the benefits. I have been using 1/4 tsp 2x a day from ovulation until yesterday.

    Thank you!

    • Hi Kim,

      Please talk to your doctor about continuing it until the 16th week of pregnancy, when the placenta will take over progesterone production. There has been no evidence that continuing the natural progesterone cream will be harmful for the baby or mother even if there are adequate progesterone levels present. Stopping it could potentially cause a drop and may lead to miscarriage. Please talk to your doctor again!

      Congratulations on your pregnancy!


  36. Avatar

    I have a 14 week old baby. I’ve been using natural progesterone cream for years to keep my endometriosis under control. Once I conceived my gp adviced me to continue using the 3% natural progesterone cream for my entire pregnancy in small amounts (1/16th tsp morning and 1/16 tsp evening every day of the month). I have had some problems in the past when using higher doses, such as adrenaline rushes, so have stuck to a low dose. My gp recommended that I continue to use the cream during the entire pregnancy and also to continue on the same dose after the baby was born which I have done.
    I am just starting to feel as if my cycles might be returning with twinges in my ovaries and feelings of pms in my stomach and my mood. Could you please offer any advice on how I should be using the cream. Should I continue to use it every day of the month? I have not yet had a period.
    Thank you for any help,
    p.s Are there any natural cures for quite severe pms?

    • Hi Elaine,

      Thank you for sharing your experience with progesterone cream! You would want to consider only using it after ovulation. I am not sure that the small amount you are using would suppress ovulation, but there is a chance of this when progesterone cream is used all month long. Learning to chart you cycle will help you to see any changes in the cycle and predict ovulation. Charting will also help you to know when to start the progesterone cream after ovulation. Since your GP knows you so well, you may want to ask for their guidance in this transition as well!

      Best Wishes,


  37. Avatar

    Hi- I’d like to address the question by the woman who said she was taking progesterone cream but it had not increased her luteal phase length. I have had excellent luck with increasing my luteal phase my taking 50 mg per day of B Complex (throughout the cycle). My progesterone levels have almost tripled and my luteal phase went from 11/12 days to 13/14. Women with luteal phase lengths of less than 12 days should consider taking up to 100 mg B Complex per day.

  38. Avatar

    I’ve been on NPC for several months now due to my levels being low. I’m trying to conceive now and am wondering if I still should be taking the NPC from cycle day 12 through menstruation or if that will suppress ovulation? Should I wait until after I know I ovulated? Thanks.

    • Hi Annie,

      Day 12 is a general estimation. If you feel that day 12 may be too soon in your cycle and are worried that you may be suppressing ovulation, it would be best to learn how to chart your cycle. Charting will help you to pin point ovulation so you can use the cream after your exact ovulation date! We have a great tool to help you learn to chart: Guide to Fertility Charting

      All the best!


  39. Avatar

    We are TTC and I am using the progesteron cream 3,000 usp. I am also now on Metformin recommended by my OBGYN and I am thinking on adding vitex to the equation but I am not sure because last time I did I had a very profuse bleeding. I don’t know when I ovulate becuase I have anovulatory cycles and PCOS so I use the cream every day for 21 days then I stop for 5 and I go back. This is my second round of progesterone cream which I started to use 2 days after de depo shot for the second time and now a month later I had today a brown discharge. Is it my period? I don’t know what to do I am waiting to see if that discharge keeps for a couple of days or not. I am also thinking of acupunture to see if we can help with this TTC process. Any sugestions? Am I doing something wrong or should I keep the metformin and the progesterone cream? Thank you so much!

    • Hi Charlotte,

      When you use natural progesterone cream everyday except the days that would be your menses, you are doing the suppression cycles. You are suppressing ovulation and increasing progesterone. I am not sure that this is right for you based on the information you have provided. Progesterone Cream is best used when there is confirmation of progesterone deficiency. If you have not had your progesterone levels tested, I urge you to do so! Using progesterone cream when you are not progesterone deficient may cause more hormonal imbalance. Depo-Provera is made from synthetic progesterone called Progestin. This injectable shot contains progestin. Progestin keeps the ovaries from releasing the eggs, thickening cervical mucous to prevent sperm from reaching the uterus and thinning the uterine lining which may prevent implantation. Note: continued use of Depo-Provera may stop the menstrual cycle completely and it may take longer than average (9 months-2 years for the menstrual cycle to regulate after stopping it). Once you have gotten a shot of Depo-provera you cannot stop it’s side effects for 12-14 weeks. It is not a good idea to use natural progesterone while also using Depo-Provera. You would not want to begin progesterone cream until the Depo-Provera was out of your system, so at least 12-14 weeks after the shot. Your doctor who prescribed the metformin should have advised you about this. Please talk to your doctor about all the supplements you are taking. I would urge you to consider stopping the natural progesterone cream. We do not suggest using NPC while also on fertility medications like Depo-Provera, which stays in the body for 3 months.

      Best Wishes,


  40. Avatar

    Hello! I have had 4 pregnancies (2children, 2 miscarriages). We are ttc #3. with all my pregnancies, I’ve had low progesterone and needed supplementation with suppositories. I was wondering if you think it’s a good idea to use NPC after ovulation to help implantation/lining. Thank you!

    • HI Sara,

      It may be best to talk to your doctor to see if you still have low progesterone. If in fact you do, then you may want to consider natural progesterone cream after ovulation up to menstruation to aid in reducing 1st trimester miscarriage.

      Best Wishes,


  41. Avatar

    Hello Dalene,
    My problem is spotting between periods, anytime between 2 to 10 days before the actual bleeding. It started after a few years of birth control (Yasmin).
    I have been trying to conceive our first child for a year now, I am 39, and the spotting has not stopped when I stopped birth control. All my tests were normal except for the TSH that was slightly elevated, as it turns I have autoimmune thyroiditis. I am taking synthroid and the TSH is now back to normal. My tubes are clear and my AMH is nice and high for someone my age so I am not premenopausal. Also, my day 21 progesterone was normal. I ovulate between cd12 and cd14 and my periods are very regular (28-29) days. I thought the spotting will stop when my thyroid issues were addressed, but I have been on treatment for nearly 3 months and despite feeling great the spotting is still there.
    Should I assume that my progesterone goes down early in my luteal phase? Could that explain infertility? And what would you recommend? Progesterone cream? Any other natural supplements?


    • Hi Christine,

      It sounds like you may have Luteal Phase Defect (LPD). Spotting during the LP is a sign of this. The most common reason for this to occur is low progesterone, but you said your progesterone levels for 21 days are fine. While natural progesterone cream supplementation may help with this, we do not recommend using it without knowing if your progesterone levels are low. There are other causes of LPD, you can learn about them here:

      The article at the link above may also help you to learn solutions for LPD.

      Best Wishes,


  42. hello , i want to start using npc and dont know where to start! i had a miscarriage and dnc last aug and since my periods are off the wall! i dont know when i ovulate and i dont know when ill get my period! sometimes ill go 2-3 months without a period! ive been using vitex for 3 months and ihavent noticed a change in anything, i know vitex works best when used over a 3-6month but i havent even gotton a period one time in the 3 months ive used vitex. i want to start using npc and if i havent gotton a period in 3months when do i start taking it? how long do i take it for? i dont know what day i ovulate on so when should i begin to take it i dont want to stop ovulation because i want to become pregnant! im so confused please help me all i want is to have a child my husband and i have been married for 8yrs and we were so excited about our pregnancy last yr after only trying for 1 month and then for it to end in a miscarriage and dnc was devastating! thanks!

  43. Avatar

    Hello I would like to start using the Natural progesterone cream for endometriosis, I have had this for almost 10 years now, and I have a regular 28 day cycle, how do I use the cream and how much? I haven’t taken anything for my endo for the past 4-5 years, and I have read a lot about the use of progesterone cream to treat endometriosis. Do I first have to see a doctor, or is it safe enough to try on my own? Please help!!!!

  44. Avatar

    This is my second cycle taking natural progesterone. My luteal phase last month didn’t improve. I ovulated on CD 18. My temperature only remained elevated for 8 days. My temperature dropped on it own and I continued 20mg of progesterone until my period on CD 28. I didn’t stop the progesterone to bring on my period. This month I ovulated on CD 18 and my temperature has remained elevated. I’m currently on CD 31 and my temperature is still elevated. I had very light spotting. Once yesterday and twice today. I’m scared to stop my progesterone in case I am pregnant, but what if I’m just delaying my period? I’m just not sure this is implantation bleeding or my period trying to start, but it’s unable to do to me still taking the progesterone. I have taken pregnancy tests and they are all negative. I’m only 12 days past ovulation…maybe it’s too soon for a postive pregnancy test. Please let me know what you think. Any help is appreciated. It just hurts so bad to miscarry and to keep thinking this will be my month. Every month is a disappointment. On the bright side, if this is my period, then it looks like I have finally extended my luteal phase, right?


    • Hi Ashley,

      I am sorry it has taken me so long to get back to you! In the future, if you need your questions replied to quickly, please contact us here:

      It would be best to NOT stop the progesterone cream if you think you are pregnant. Tests may come out negative early in pregnancy. You can learn how to use progesterone for Pregnancy at this link: (scroll toward the bottom of the page).

      It can take some time, 3 or more cycles for your body to adjust and get into a rhythm when using any type of supplement, including progesterone cream.

      Best Wishes,


  45. Avatar

    I am 51 years old. I have been going through “menopause” for about 2 years. Sometimes I will get a period every month for a few months, then I will go without periods (but will have light cramping and extra tiredness and sometimes low back ache) for about a week around the time I would have had my period. I was thinking that I should do a menopause cleanse. Woudl you suggest taking maca? I already take dong quai when I feel estrogen-dominant. I don’t really have any hot flashes, but my hair falls out. I have low thyroid and take thyroid animal glandular extracts. What do you recommend? I certainly am not interested in conceiving.

    • Hi Cathy,

      I am sorry, but we are solely focused on the fertile times in a woman’s life, as well as fertility issues or healing that may need to take place. We have not moved toward any menopausal remedies, education, or work as of yet. Because of this I feel it is best for you to find a practitioner in your area to work with for natural menopausal support. I would love to direct you to a great informational website on menopausal remedies, but there are none that I have found yet that I would support that do not have tons of adds. Try doing a search on the internet. Your best bet would be working with a naturopathic doctor or herbalist in your area.

      Best Wishes,


  46. Avatar

    This is my first cycle using 20mg (1 dropperful of progestelle) and I am currently 14-16DPO. I have PCOS and irregular periods. I have been charting BBT to determine ovulation since it varies so much. My LP is generally13-15days.

    My question is the following; if I’m not pregnant will my period start while I’m using the progesterone, or do I need to stop it in order for it to start?

    I don’t want to keep having to take pregnancy tests 12,13,14,15DPO and delay stopping the progesterone/and my period if I am not pregnant, but on the other hand I don’t want to stop the progesterone at all if I am pregnant. It may take until 16-18DPO to know for sure if my period doesn’t show while I’m taking the progesterone.

    • Hi Brianna,

      It sounds like you are in a pickle and you are just trying to adjust to using progesterone for your first time. You are going to have to get used to waiting to take a pregnancy test until you know that it is for sure a good time to test to get a positive result. You may have to stop the progesterone use to bring on your cycle, though it should naturally decline on its own to bring on natural menstruation. Many women find that they need to create a cycle with progesterone, once they do this they can then chart more easily and know when to stop the cream or continue it. This will also help you to know when you should take a pregnancy test. You can learn more about Progesterone use here:

      Best Wishes,


  47. Avatar

    If I start my period early — while I’m still using the Progesterone Cream, do I stop using it until my period is over or continue the cream like normal?

  48. Avatar

    If i am using progesterone cream, cos my progesterone is low and i am trying to conceive, will my cycle come out naturally if i am not pregnant

    • Hi Udeka,

      There is no way for me to know if your cycle will come on naturally with the use of Natural Progesterone Cream, it may or may not depending on what your fertility challenges are.

      Many of our readers know they want to try natural therapies to help boost their fertility but don’t know which ones are bet for their personal situation.

      If you are someone who has questions about what natural fertility therapies may be right for you, you may want to consider a Natural Fertility Consultation.

      If you have low progesterone and that is one of your main fertility challenges you may want to learn more about the use of Natural Progesterone Cream at this link:

      Best Wishes,